An inhibitor of the protein-protein interaction between SAP and amyloid fibrils
Related Products
Pro-drug Form(s)
36559GSK3039294
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals

Research Area

Cardiovascular System
Blood
Acute Phase Reactants

CPHPC

Item No. 75500

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1'-(1,6-dioxo-1,6-hexanediyl)bis-D-proline
CAS Number
224624-80-0
Synonyms
  • GSK2315698
  • Miridesap
  • Ro 63-8695
Molecular Formula
C16H24N2O6
Formula Weight
340.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(CCCCC(N1CCC[C@@H]1C(O)=O)=O)N2[C@@H](C(O)=O)CCC2
InChi Code
InChI=1S/C16H24N2O6/c19-13(17-9-3-5-11(17)15(21)22)7-1-2-8-14(20)18-10-4-6-12(18)16(23)24/h11-12H,1-10H2,(H,21,22)(H,23,24)
InChi Key
HZLAWYIBLZNRFZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $69

    Add

    10 mg

    $127

    Add

    50 mg

    $525

    Add
    Product Description

    CPHPC is an inhibitor of the protein-protein interaction between serum amyloid P (SAP) and amyloid fibrils (IC50 = 0.9 µM).1 It also crosslinks with pentameric SAP in the plasma to form a decameric complex, which is eliminated via hepatic clearance. As plasma and amyloid deposits of SAP exist in a dynamic equilibrium, CPHPC induces the dissociation of SAP from tissue amyloid deposits, leading to its redistribution into the plasma, where it is eliminated. DPHC (1 mg/ml in the drinking water) reduces serum human SAP levels in a transgenic mouse model of amyloidosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pepys, M.B., Herbert, J., Hutchinson, W.L., et al. Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature 417(6886), 254-259 (2002).