An AT1 receptor antagonist
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ZD 7155 (hydrochloride)

Item No. 36576

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-diethyl-3,4-dihydro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one, monohydrochloride
CAS Number
146709-78-6
Molecular Formula
C26H26N6O • HCl
Formula Weight
475.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mM
SMILES
O=C1N(CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)C5=CC(CC)=NC(CC)=C5CC1.Cl
InChi Code
InChI=1S/C26H26N6O.ClH/c1-3-19-15-24-22(23(4-2)27-19)13-14-25(33)32(24)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)26-28-30-31-29-26;/h5-12,15H,3-4,13-14,16H2,1-2H3,(H,28,29,30,31);1H
InChi Key
NAGGAAHTUXEGFG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $109

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    10 mg

    $203

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    25 mg

    $465

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    Product Description

    ZD 7155 is a nonpeptide antagonist of the angiotensin II type 1 (AT1) receptor (IC50 = 3.3 nM).1 It inhibits angiotensin II-induced pressor responses in conscious normotensive rats in a dose-dependent manner and decreases mean arterial pressure in conscious spontaneously hypertensive rats when administered at a dose of 1.082 µmol/kg.2 ZD 7155 (10 mg/kg in the drinking water) improves motor nerve conduction velocity in the sciatic nerve in a rat model of streptozotocin-induced diabetic neuropathy.3 It decreases disease severity and NF-κB and activator protein 1 (AP-1) activation in a mouse model of LPS-induced acute lung injury when administered at a dose of 10 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, H., Unal, H., Gati, C., et al. Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. Cell 161(4), 833-844 (2015).

    2. Junggren, I.L., Zhao, X., Sun, X., et al. Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat. J. Pharm. Pharmacol. 48(8), 829-833 (1996).

    3. Maxfield, E.K., Love, A., Cotter, M.A., et al. Nerve function and regeneration in diabetic rats: Effects of ZD-7155, an AT1 receptor antagonist. Am. J. Physiol. 269(3 Pt 1), E530-537 (1995).

    4. Wang, F., Xia, Z.-F., Chen, X.-L., et al. Angiotensin II type-1 receptor antagonist attenuates LPS-induced acute lung injury. Cytokine 48(3), 246-253 (2009).