An AT1 receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ZD 7155 (hydrochloride)

Item No. 36576

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-diethyl-3,4-dihydro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one, monohydrochloride
CAS Number
146709-78-6
Molecular Formula
C26H26N6O • HCl
Formula Weight
475.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mM
SMILES
O=C1N(CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)C5=CC(CC)=NC(CC)=C5CC1.Cl
InChi Code
InChI=1S/C26H26N6O.ClH/c1-3-19-15-24-22(23(4-2)27-19)13-14-25(33)32(24)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)26-28-30-31-29-26;/h5-12,15H,3-4,13-14,16H2,1-2H3,(H,28,29,30,31);1H
InChi Key
NAGGAAHTUXEGFG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $32

    Add

    5 mg

    $109

    Add

    10 mg

    $203

    Add

    25 mg

    $465

    Add
    Product Description

    ZD 7155 is a nonpeptide antagonist of the angiotensin II type 1 (AT1) receptor (IC50 = 3.3 nM).1 It inhibits angiotensin II-induced pressor responses in conscious normotensive rats in a dose-dependent manner and decreases mean arterial pressure in conscious spontaneously hypertensive rats when administered at a dose of 1.082 µmol/kg.2 ZD 7155 (10 mg/kg in the drinking water) improves motor nerve conduction velocity in the sciatic nerve in a rat model of streptozotocin-induced diabetic neuropathy.3 It decreases disease severity and NF-κB and activator protein 1 (AP-1) activation in a mouse model of LPS-induced acute lung injury when administered at a dose of 10 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, H., Unal, H., Gati, C., et al. Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. Cell 161(4), 833-844 (2015).

    2. Junggren, I.L., Zhao, X., Sun, X., et al. Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat. J. Pharm. Pharmacol. 48(8), 829-833 (1996).

    3. Maxfield, E.K., Love, A., Cotter, M.A., et al. Nerve function and regeneration in diabetic rats: Effects of ZD-7155, an AT1 receptor antagonist. Am. J. Physiol. 269(3 Pt 1), E530-537 (1995).

    4. Wang, F., Xia, Z.-F., Chen, X.-L., et al. Angiotensin II type-1 receptor antagonist attenuates LPS-induced acute lung injury. Cytokine 48(3), 246-253 (2009).