An AChE modulator
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Isomer(s)
18607Asoxime (chloride)
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Obidoxime (chloride)

Item No. 36587

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1′-[oxybis(methylene)]bis[4-[(hydroxyimino)methyl]-pyridinium, dichloride
CAS Number
114-90-9
Synonyms
  • Toxogonin
Molecular Formula
C14H16N4O3 • 2Cl
Formula Weight
359.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly SolubleDMSO: Slightly SolublePBS (pH 7.2): 10 mg/ml
λmax
301 nm
SMILES
ON=CC1=CC=[N+](COC[N+]2=CC=C(C=C2)C=NO)C=C1.[Cl-].[Cl-]
InChi Code
InChI=1S/C14H14N4O3.2ClH/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20;;/h1-10H,11-12H2;2*1H
InChi Key
ZIFJVJZWVSPZLE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    250 mg

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    500 mg

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    1 g

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    Product Description

    Obidoxime is an acetylcholinesterase (AChE) modulator.1 It induces inhibition and activation of bovine erythrocyte AChE in the presence and absence of ACh, respectively, when used at a concentration of 3 mM. Obidoxime (10.5 mg/kg) induces reactivation of tabun-inhibited AChE in rat blood and diaphragm and reduces tabun-induced lethality in mice.2 Intranasal administration of obidoxime reduces seizure duration and severity and prevents mortality in a rat model of paraoxon-induced organophosphate poisoning.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuhnen, H. Activating and inhibitory effects of bispyridinium compounds on bovine red cell acetylcholinesterase. Toxicol. Appl. Pharmacol. 20(1), 97-104 (1971).

    2. Kassa, J., Karasova, J., Musilek, K., et al. An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology 243(3), 311-316 (2008).

    3. Krishnan, J.K.S., Arun, P., Appu, A.P., et al. Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning. Neurotoxicology 53, 64-73 (2016).