A p70S6K1 inhibitor
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S6K-18

Item No. 36624

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(1,1-dimethylethyl)-2-[[(1H-indazol-5-ylamino)carbonyl]amino]-3-thiophenecarboxylic acid
CAS Number
1265789-88-5
Molecular Formula
C17H18N4O3S
Formula Weight
358.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 2 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): insol
λmax
225, 313 nm
SMILES
O=C(C1=C(NC(NC2=CC3=C(NN=C3)C=C2)=O)SC(C(C)(C)C)=C1)O
InChi Code
InChI=1S/C17H18N4O3S/c1-17(2,3)13-7-11(15(22)23)14(25-13)20-16(24)19-10-4-5-12-9(6-10)8-18-21-12/h4-8H,1-3H3,(H,18,21)(H,22,23)(H2,19,20,24)
InChi Key
BSRFCMMJUFQEOX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $135

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    25 mg

    $300

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    50 mg

    $487

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    Product Description

    S6K-18 is an inhibitor of p70 ribosomal S6 kinase 1 (p70S6K1; IC50 = 52 nM).1 It is selective for p70S6K1 over a panel of 43 kinases at 1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ye, P., Kuhn, C., Juan, M., et al. Potent and selective thiophene urea-templated inhibitors of S6K. Bioorg. Med. Chem. Lett. 21(2), 849-852 (2011).