An ILK inhibitor
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ILK-IN-2

Item No. 36674

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]-1H-pyrazole-3-propanamide
CAS Number
1333146-24-9
Synonyms
  • CPD 22
  • Integrin-linked Kinase Inhibitor 1
  • OSU-T 315
Molecular Formula
C30H30F3N5O
Formula Weight
533.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10mM
λmax
269 nm
SMILES
FC(F)(F)C1=CC=C(C2=CC=C(C3=CC(CCC(NC)=O)=NN3C4=CC=C(N5CCNCC5)C=C4)C=C2)C=C1
InChi Code
InChI=1S/C30H30F3N5O/c1-34-29(39)15-10-25-20-28(38(36-25)27-13-11-26(12-14-27)37-18-16-35-17-19-37)23-4-2-21(3-5-23)22-6-8-24(9-7-22)30(31,32)33/h2-9,11-14,20,35H,10,15-19H2,1H3,(H,34,39)
InChi Key
GHBUPSVATJKTRR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $192

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    5 mg

    $525

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    10 mg

    $666

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    Product Description

    ILK-IN-2 is an inhibitor of integrin-linked kinase (ILK; IC50 = 0.6 µM).1 It inhibits the phosphorylation of Akt, glycogen synthase kinase 3β (GSK3β), and myosin light-chain (MLC) in PC3 prostate and MDA-MB-231 breast cancer cells when used at concentrations ranging from 1 to 4 µM. ILK-IN-2 inhibits the proliferation of LNCaP, PC3, MDA-MB-231, MDA-MB-468, SK-BR-3, and MCF-7 cancer cells (IC50s = 1.6, 2, 1, 1.5, 1.8, and 2.5 µM, respectively), as well as induces autophagy and apoptosis in PC3 cells when used at a concentration of 2 µM. It also reduces protein levels of Y-box binding protein (YB-1), HER2, and EGFR in PC3 cells. ILK-IN-2 (25 and 50 mg/kg) reduces tumor growth in a PC3 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, S.-L., Hsu, E.-C., Chou, C.-C., et al. Identification and characterization of a novel integrin-linked kinase inhibitor. J. Med. Chem. 54(18), 6364-6374 (2011).