A metabolite of nicotinic acid and a uremic toxin
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Isomer(s)
29920JBSNF-000088
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N-Methyl-4-pyridone-5-carboxamide

Item No. 36684

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-1-methyl-4-oxo-3-pyridinecarboxamide
CAS Number
769-49-3
Synonyms
  • Me4PY
Molecular Formula
C7H8N2O2
Formula Weight
152.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Slightly solublePBS (pH 7.2): 5 mg/ml
λmax
269 nm
SMILES
O=C(C1=CN(C)C=CC1=O)N
InChi Code
InChI=1S/C7H8N2O2/c1-9-3-2-6(10)5(4-9)7(8)11/h2-4H,1H3,(H2,8,11)
InChi Key
KTLRWTOPTKGYQY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $120

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    10 mg

    $228

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    50 mg

    $840

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    100 mg

    $1,439

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    Product Description

    N-Methyl-4-pyridone-5-carboxamide is a metabolite of nicotinic acid and a uremic toxin.1,2 Plasma levels of N-methyl-4-pyridone-5-carboxamide are increased and positively correlated with serum levels of malondialdehyde (MDA) in patients with chronic kidney disease (CKD).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, M.L.W., and Johnson, B.C. N-Methyl-4-pyridone-5-carboxamide as a metabolite of nicotinic acid in man and monkey. The Journal of Biological Chemisty 236, 2096-2098 (1961).

    2. Rutkowski, P., Słominska, E.M., Szołkiewicz, M., et al. Relationship between uremic toxins and oxidative stress in patients with chronic renal failure. Scand. J. Urol. Nephrol. 41(3), 243-248 (2007).