An α2-adrenergic receptor agonist
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Xylazine (hydrochloride)

Item No. 36692

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine, monohydrochloride
CAS Number
23076-35-9
Synonyms
  • BAY-Va 1470
Molecular Formula
C12H16N2S • HCl
Formula Weight
256.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 50 mg/ml
λmax
212 nm
SMILES
CC1=C(C(C)=CC=C1)NC2=NCCCS2.Cl
InChi Code
InChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H
InChi Key
QYEFBJRXKKSABU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $29

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    1 g

    $51

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    5 g

    $169

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    Product Description

    Xylazine is an agonist of α2-adrenergic receptors (Ki = 194 nM).1 It is an analog of clonidine, an α2-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals.2,3 This product is also available as an analytical reference standard (Item Nos. 37854 | 22641).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Virtanen, R., Savola, J.M., Saano, V., et al. Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist. Eur. J. Pharmacol. 150(1-2), 9-14 (1988).

    2. Richardson, C.A., and Flecknell, P.A. Anaesthesia and post-operative analgesia following experimental surgery in laboratory rodents: Are we making progress? Altem. Lab. Anim. 33(2), 119-127 (2005).

    3. Vallverde, A. Alpha-2 agonists as pain therapy in horses. Vet. Clin. North Am. Equine Pract. 26(3), 515-532 (2010).

    Product Citations

    Kang, J., Xu, R., Lee, S., et al. Discovery, structural characterization, and preclinicla evaluation of monoclonal antibodies against xylazine poisoning. ACS Pharmacol. Transl. Sci. (2026).