An ionizable lipomer
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cKK-E12

Item No. 36700

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]-2,5-piperazinedione
CAS Number
1432494-65-9
Molecular Formula
C60H120N4O6
Formula Weight
993.6
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleEthanol: SolubleMethanol: Soluble
SMILES
O=C1NC(CCCCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)C(NC1CCCCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)=O
InChi Code
InChI=1S/C60H120N4O6/c1-5-9-13-17-21-25-29-33-41-53(65)49-63(50-54(66)42-34-30-26-22-18-14-10-6-2)47-39-37-45-57-59(69)62-58(60(70)61-57)46-38-40-48-64(51-55(67)43-35-31-27-23-19-15-11-7-3)52-56(68)44-36-32-28-24-20-16-12-8-4/h53-58,65-68H,5-52H2,1-4H3,(H,61,70)(H,62,69)
InChi Key
ZISVTYVLWSZJAL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $270

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    10 mg

    $432

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    25 mg

    $876

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    50 mg

    $1,348

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    Cayman Chemical
    Ionizable Lipids – Your Path from R&D to GMP

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    Product Description

    cKK-E12 is an ionizable lipomer that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.1,2 LNPs containing cKK-E12, in combination with L-319 (Item No. 35051), and encapsulating varicella-zoster virus (VZV) mRNA encoding glycoprotein E (gE) increase the lymph node and spleen levels of CD11c+CD80+ and CD11c+CD86+ cells and total serum IgG titers in mice, as well as decrease the number of VZV-induced rashes and the epithelial levels of VZV DNA in a guinea pig model of VZV-induced shingles.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hatit, M.Z.C., Lokugamage , M.P., Dobrowolski, C.N., et al. Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles. Nat. Nanotechnol. 17(3), 310-318 (2022).

    2. Cheng, X., Liu, S., Sun, J., et al. A synergistic lipid nanoparticle encapsulating mRNA shingles vaccine induces potent immune responses and protects guinea pigs from viral challenges. Adv. Mat. 36(13), e2310886 (2023).