An Analytical Reference Standard
Features
  • This product has been formulated as an exempt preparation which meets criteria established by the US DEA
  • Possession of a DEA Controlled Substance registration is not necessary nor is a DEA 222 form required to purchase this product
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for academic research at qualified institutions; please contact our sales department for pricing
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4-ANPP-d5 (exempt preparation)

Item No. 36781

Exempt Product (US)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 4-Aminophenyl-1-phenethylpiperidine-d5
  • 4-Anilino-N-phenethylpiperidine-d5
  • Despropionyl fentanyl-d5
Technical Information
Formal Name
N-phenyl-d5-1-(2-phenylethyl)-4-piperidinamine
CAS Number
1189466-15-6
Molecular Formula
C19H19D5N2
Formula Weight
285.4
Purity
≥99% deuterated forms (d1-d5)
Formulation
A 1 mg/ml solution in methanol
SMILES
[2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1NC2CCN(CCC3=CC=CC=C3)CC2
InChi Code
InChI=1S/C19H24N2/c1-3-7-17(8-4-1)11-14-21-15-12-19(13-16-21)20-18-9-5-2-6-10-18/h1-10,19-20H,11-16H2/i2D,5D,6D,9D,10D
InChi Key
ZCMDXDQUYIWEKB-OUHXUHDZSA-N
Regulatory Information
DEA Exempt Notification
This product is a DEA exempt preparation of a scheduled compound - does not require DEA Controlled Substance registration or DEA 222 form. For alternate sizes please contact sales.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

    $238

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    Product Description

    4-ANPP-d5 (exempt preparation) (Item No. 36781) is intended for use as an internal standard for the quantification of 4-ANPP (Item Nos. 22700 | 18810) by GC- or LC-MS. 4-ANPP is categorized as an opioid metabolite and a precursor in the synthesis of fentanyl (Item Nos. ISO60197 | 22659 | 14719) and other opioids.1,2,3,4,5 4-ANPP is a metabolite of acetyl fentanyl (Item Nos. ISO60128 | ISO00128), butyryl fentanyl (Item Nos. 19734 | 14728), furanyl fentanyl (Item Nos. 19633 | 18705), acrylfentanyl (Item Nos. 23060 | 19312), and fentanyl.1,2,3,4 It has also been found as an impurity in illicit fentanyl preparations.6 4-ANPP-d5 is regulated as a Schedule II compound in the United States. 4-ANPP-d5 (exempt preparation) (Item No. 36781) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Watanabe, S., Vikingsson, S., Roman, M., et al. In vitro and in vivo metabolite identification studies for the new synthetic opioids acetylfentanyl, acrylfentanyl, furanylfentanyl, and 4-fluoro-isobutyrylfentanyl. AAPS J. 19(4), 1102-1122 (2017).

    2. Labroo, R.B., Paine, M.F., Thummel, K.E., et al. Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: Implications for interindividual variability in disposition, efficacy, and drug interactions. Drug Metab. Dispos. 25(9), 1072-1079 (1997).

    3. Melent'ev, A.B., Kataev, S.S., and Dvorskaya, O.N. Identification and analytical properties of acetyl fentanyl metabolites. J. Anal. Chem. 70(2), 216-224 (2015).

    4. Steuer, A.E., Williner, E., Staeheli, S.N., et al. Studies on the metabolism of the fentanyl-derived designer drug butyrfentanyl in human in vitro liver preparations and authentic human samples using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Drug Test Anal. 9(7), 1085-1092 (2017).

    5. Pease, J.P., LePine, A.J., and Smith, C.M. Methods for preparing fentanyl and fentanyl intermediates. Patent Application Publication US2013/0281702A1, (2013).

    6. Lurie, I.S., Berrier, A.L., Casale, J.F., et al. Profiling of illicit fentanyl using UHPLC-MS/MS. Forensic Sci. Int. 220(1-3), 191-196 (2012).