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Fentanyl (citrate)

Item No. 22659

Restricted Product (Schedule II)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide, 2-hydroxy-1,2,3-propanetricarboxylate
CAS Number
990-73-8
Molecular Formula
C22H28N2O • C6H8O7
Formula Weight
528.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12.5 mg/mlDMSO: 10 mg/mlEthanol: 0.2 mg/mlPBS (pH 7.2): 1.67 mg/ml
SMILES
O=C(N(C1=CC=CC=C1)C2CCN(CCC3=CC=CC=C3)CC2)CC.OC(CC(O)=O)(C(O)=O)CC(O)=O
InChi Code
InChI=1S/C22H28N2O.C6H8O7/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-12,21H,2,13-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChi Key
IVLVTNPOHDFFCJ-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
II
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Fentanyl (citrate) (Item No. 22659) is an analytical reference standard categorized as an opioid.1,2 It is more effective than morphine (Item No. ISO60147) at reducing pain but is also more lethal.3 Fentanyl is highly abused and is associated with many fatal overdoses.4 Fentanyl is regulated as a Schedule II substance in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burns, S.M., Cunningham, C.W., and Mercer, S.L. DARK classics in chemical neuroscience: Fentanyl. ACS Chem. Neurosci. 9(10), 2428-2437 (2018).

    2. Raynor, K., Kong, H., Chen, Y., et al. Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors. Mol. Pharm. 45(2), 330-334 (1994).

    3. Higashikawa, Y., and Suzuki, S. Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues. Forensic Toxicol. 26(1), 1-5 (2008).

    4. Armenian, P., Vo, K.T., Barr-Walker, J., et al. Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review. Neuropharmacology 134(Pt A), 121-132 (2018).

    Product Citations

    Kang, J., Xu, R., Lee, S., et al. Discovery, structural characterization, and preclinicla evaluation of monoclonal antibodies against xylazine poisoning. ACS Pharmacol. Transl. Sci. (2026).

    Varshneya, N.B., Hassanien, S.H., Holt, M.C., et al. Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression. Pharmacol. Biochem. Behav. 226, 173572 (2023).

    Varshneya, N.B., Hassanien, S.H., Holt, M.C., et al. Respiratory depressant effects of fentanyl analogs are opioid receptor-mediated. Biochem. Pharmacol. 195, 114805 (2022).

    Hassanien, S.H., Bassman, J.R., Perrien Naccarato, C.M., et al. In vitro pharmacology of fentanyl analogs at the human mu opioid receptor and their spectroscopic analysis. Drug Test. Anal. 12(8), 1212-1221 (2020).