A synthetic lipolytic peptide
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AOD-9604 (acetate)

Item No. 36790

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclic (7→14)-disulfide, L-tyrosyl-L-leucyl-L-arginyl-L-isoleucyl-L-valyl-L-glutaminyl-L-cysteinyl-L-arginyl-L-seryl-L-valyl-L-α-glutamylglycyl-L-seryl-L-cysteinylglycyl-L-phenylalanine, acetate
Synonyms
  • Anti-obesity Drug 9604
Molecular Formula
C78H123N23O23S2 • XC2H4O2
Formula Weight
1815.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble
SMILES
OC(C=C1)=CC=C1C[C@H](N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]2C(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CSSC2)C(NCC(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)=O)=O)CO)=O)=O)CCC(O)=O)=O)C(C)C)=O)CO)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
InChi Code
InChI=1S/C78H123N23O23S2.C2H4O2/c1-9-41(8)62(101-68(115)47(18-14-28-86-78(83)84)91-69(116)50(29-38(2)3)95-63(110)45(79)30-43-19-21-44(104)22-20-43)75(122)100-61(40(6)7)74(121)94-49(23-25-56(80)105)67(114)98-55-37-126-125-36-54(65(112)88-32-57(106)89-51(76(123)124)31-42-15-11-10-12-16-42)97-70(117)52(34-102)90-58(107)33-87-64(111)48(24-26-59(108)109)93-73(120)60(39(4)5)99-71(118)53(35-103)96-66(113)46(92-72(55)119)17-13-27-85-77(81)82;1-2(3)4/h10-12,15-16,19-22,38-41,45-55,60-62,102-104H,9,13-14,17-18,23-37,79H2,1-8H3,(H2,80,105)(H,87,111)(H,88,112)(H,89,106)(H,90,107)(H,91,116)(H,92,119)(H,93,120)(H,94,121)(H,95,110)(H,96,113)(H,97,117)(H,98,114)(H,99,118)(H,100,122)(H,101,115)(H,108,109)(H,123,124)(H4,81,82,85)(H4,83,84,86);1H3,(H,3,4)/t41-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,60+,61-,62-;/m0./s1
InChi Key
UABQRJZABFFQRR-UPOQWEFCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    AOD-9604 is a synthetic lipolytic 15-amino acid peptide fragment derived from human growth hormone.1,2 In vivo, AOD-9604 (250 µg/kg per day) decreases body weight, epididymal adipose tissue mass, and brown adipose tissue weight in ob/ob mice.1 It also enhances cartilage regeneration in a rabbit model of collagenase-induced knee osteoarthritis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heffernan, M., Summers, R.J., Thorburn, A., et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and β3-AR knock-out mice. Endocrinology 142(12), 182-189 (2001).

    2. Kwon, D.R., and Park, G.Y. Effect of intra-articular injection of AOD9604 with or without hyaluronic acid in rabbit osteoarthritis model. Ann. Clin. Lab. Sci. 45(4), 426-432 (2015).