A Certified Reference Material
Features
  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This CRM has been characterized by metrologically valid procedures and may be used as a quantitative analytical reference standard
  • Certificate of analysis provides the certified property values and the associated uncertainties, including a statement of metrological traceability for the certified values
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
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Noroxycodone-d3 (hydrochloride) (CRM)

A 100 μg/ml solution in methanol

Item No. 36792

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5α)-(4,5)-epoxy-14-hydroxy-3-(methoxy-d3)-morphinan-6-one, monohydrochloride
CAS Number
1426174-79-9
Molecular Formula
C17H16D3NO4 • HCl
Formula Weight
340.8
Formulation
A 100 μg/ml solution in methanol
SMILES
O[C@]12[C@]3(CCN[C@@H]2C4)[C@](OC5=C3C4=CC=C5OC([2H])([2H])[2H])([H])C(CC1)=O.Cl
InChi Code
InChI=1S/C17H19NO4.ClH/c1-21-11-3-2-9-8-12-17(20)5-4-10(19)15-16(17,6-7-18-12)13(9)14(11)22-15;/h2-3,12,15,18,20H,4-8H2,1H3;1H/t12-,15+,16+,17-;/m1./s1/i1D3;
InChi Key
IGNAMRAQFUFUMH-HHAOZYOFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $123

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    Product Description

    Noroxycodone-d3 (hydrochloride) (CRM) is intended for use as an internal standard for the quantification of noroxycodone (Item Nos. 35521 | 27217) by GC- or LC-MS. Noroxycodone is categorized as an opioid.1,2 Noroxycodone is a metabolite of oxycodone (Item Nos. ISO60148 | 15465 | 26513).3,4 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leow, K.P., and Smith, M.T. The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats. Life Sci. 54(17), 1229-1236 (1994).

    2. Lalovic, B., Kharasch, E., Hoffer, C., et al. Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites. Clin. Pharmacol. Ther. 79(5), 461-479 (2006).

    3. Romand, S., Spaggiari, D., Marsousi, N., et al. Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases. J. Pharm. Biomed. Anal. 144, 129-137 (2017).

    4. Fang, W.B., Lofwall, M.R., Walsh, S.L., et al. Determination of oxycodone, noroxycodone and oxymorphone by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry in human matrices: In vivo and in vitro applications. J. Anal. Toxicol. 37(6), 337-344 (2013).