A paraben
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Isomer(s)
24909Zingerone
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Butyl 4-hydroxybenzoate

Item No. 36797

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-benzoic acid, butyl ester
CAS Number
94-26-8
Synonyms
  • Butoben
  • Butyl p-hydroxybenzoate
  • Butyl para-hydroxybenzoate
  • Butylparaben
  • p-Hydroxybenzoic Acid butyl ester
  • NSC 8475
  • NSC 13164
  • Tegosept B
Molecular Formula
C11H14O3
Formula Weight
194.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 0.25 mg/ml
λmax
258 nm
SMILES
O=C(C1=CC=C(C=C1)O)OCCCC
InChi Code
InChI=1S/C11H14O3/c1-2-3-8-14-11(13)9-4-6-10(12)7-5-9/h4-7,12H,2-3,8H2,1H3
InChi Key
QFOHBWFCKVYLES-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    250 g

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    Cayman Chemical
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    Product Description

    Butyl 4-hydroxybenzoate is a paraben that has been found in Microbulbifer.1 It is active against the Gram-positive bacteria B. subtilis and S. aureus, yeast C. molischiana and S. cerevisiae, and fungi A. niger and P. chrysogenum (MICs = 75, 75, 60, 52, 55, and 45 mg/L, respectively). Butyl 4-hydroxybenzoate (300-1,000 µM) decreases the viability of, and ATP and glutathione (GSH) levels in, HepG2 and human dermal fibroblast neonatal (HDFn) cells.2 It binds to estrogen receptors in a concentration-dependent manner and increases uterine weight in immature and ovariectomized rats.3 Butyl 4-hydroxybenzoate has been found in influent and effluent wastewater.4 Formulations containing butyl 4-hydroxybenzoate have been used as preservatives in cosmetics, food, and pharmaceuticals.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peng, X., Adachi, K., Chen, C., et al. Discovery of a marine bacterium producing 4-hydroxybenzoate and its alkyl esters, parabens. Appl. Environ. Microbiol. 72(8), 5556-5561 (2006).

    2. Kizhedath, A., Wilkinson, S., and Glassey, J. Assessment of hepatotoxicity and dermal toxicity of butyl paraben and methyl paraben using HepG2 and HDFn in vitro models. Toxicol. In Vitro 55, 108-115 (2019).

    3. Routledge, E.J., Parker, J., Odum, J., et al. Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic. Toxicol. Appl. Pharmacol. 153(1), 12-19 (1998).

    4. Wang, W., and Kannan, K. Fate of parabens and their metabolites in two wastewater treatment plants in New York state, United States. Environ. Sci. Technol. 50(3), 1174-1181 (2016).