A prodrug form of SPI 112
Related Products
Active Metabolite(s)
29474SPI 112
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SPI 112Me

Item No. 36819

Product Insert (PDF)
Technical Information
Formal Name
3-[(2Z)-2-[5-[[[(4-fluorophenyl)methyl]amino]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]hydrazinyl]-benzoic acid, methyl ester
CAS Number
1243685-62-2
Molecular Formula
C23H19FN4O5S
Formula Weight
482.5
Purity
≥90%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble: ≥10 mg/mlDMSO: Soluble: ≥10 mg/ml
SMILES
COC(C1=CC=CC(N/N=C2C3=CC(S(NCC4=CC=C(C=C4)F)(=O)=O)=CC=C3NC/2=O)=C1)=O
InChi Code
InChI=1S/C23H19FN4O5S/c1-33-23(30)15-3-2-4-17(11-15)27-28-21-19-12-18(9-10-20(19)26-22(21)29)34(31,32)25-13-14-5-7-16(24)8-6-14/h2-12,25,27H,13H2,1H3,(H,26,28,29)
InChi Key
AFUSXRUYBQFNGT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    5 mg

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    10 mg

    $160

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    25 mg

    $254

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    Cayman Chemical
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    Product Description

    SPI 112Me is a prodrug form of the Src homology region 2 domain-containing phosphatase 2 (SHP-2) inhibitor SPI 112 (Item No. 29474).1 It is hydrolyzed by esterases intracellularly to form SPI 112. SPI 112Me inhibits the protein tyrosine phosphatase (PTP) activity of SHP-2 containing a constitutively activating glutamate-to-lysine substitution at position 76 (SHP-2E76K) in TF-1 leukemia cells expressing the mutant enzyme. SPI 112Me (20 µM) inhibits Paxillin dephosphorylation, ERK1/2 activation, and cell migration in EGF-stimulated MDA-MB-468 breast cancer cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, L., Pernazza, D., Scott, L.M., et al. Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112. Biochem. Pharmacol. 80(6), 801-810 (2010).