A PTP1B inhibitor
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PTP1B-IN-2

Item No. 36824

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[[4-[(2-methoxy-2-oxoethyl)(methylsulfonyl)amino]phenyl]methyl][(phenylmethyl)sulfonyl]amino]-2-[(4-methylphenyl)methoxy]-benzoic acid, methyl ester
CAS Number
1919853-46-5
Synonyms
  • Protein Tyrosine Phosphatase 1B Inhibitor 2
  • PTPN1 Inhibitor 2
  • Tyrosine-protein Phosphatase Non-Receptor Type 1 Inhibitor 2
Molecular Formula
C34H36N2O9S2
Formula Weight
680.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
SMILES
O=C(C1=CC(N(S(=O)(CC2=CC=CC=C2)=O)CC3=CC=C(N(S(=O)(C)=O)CC(OC)=O)C=C3)=CC=C1OCC4=CC=C(C)C=C4)OC
InChi Code
InChI=1S/C34H36N2O9S2/c1-25-10-12-27(13-11-25)23-45-32-19-18-30(20-31(32)34(38)44-3)36(47(41,42)24-28-8-6-5-7-9-28)21-26-14-16-29(17-15-26)35(46(4,39)40)22-33(37)43-2/h5-20H,21-24H2,1-4H3
InChi Key
IPNJQCVHNPGYOX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $53

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    10 mg

    $95

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    25 mg

    $159

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    PTP1B-IN-2 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50 = 50 nM).1 It is selective for PTP1B over T cell protein tyrosine phosphatase (TCPTP), Src homology region 2 domain-containing phosphatase 1 (SHP-1), SHP-2, and leukocyte common antigen-related (LAR) phosphatase (IC50s = 760, 2,450, 2,160, and 12,610 nM, respectively). PTP1B-IN-2 (5-20 µM) enhances insulin-induced glucose uptake in L6 myotubes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, P., Du, Y., Song, L., et al. Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity. Eur. J. Med. Chem. 118, 27-33 (2016).