An inverse agonist of GPR3
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AF64394

Item No. 36826

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[4-chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
CAS Number
1637300-25-4
Molecular Formula
C21H20ClN5O
Formula Weight
393.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
253 nm
SMILES
ClC1=CC=C(CNC2=CC(C3=CC=CC=C3)=NC4=NC=NN42)C(OC(C)C)=C1
InChi Code
InChI=1S/C21H20ClN5O/c1-14(2)28-19-10-17(22)9-8-16(19)12-23-20-11-18(15-6-4-3-5-7-15)26-21-24-13-25-27(20)21/h3-11,13-14,23H,12H2,1-2H3
InChi Key
WBYNZQXAAWPAGR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $62

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    10 mg

    $153

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    25 mg

    $274

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    Product Description

    AF64394 is an inverse agonist of the orphan G protein-coupled receptor GPR3.1 It selectively inhibits cAMP accumulation in HEK293 cells expressing GPR3 over GPR6 or GPR12 (IC50s = 0.5, 7.9, and 12 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jensen, T., Elster, L., Nielsen, S.M., et al. The identification of GPR3 inverse agonist AF64394; The first small molecule inhibitor of GPR3 receptor function. Bioorg. Med. Chem. Lett. 24(22), 5195-5198 (2014).