A survivin inhibitor
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Alternative(s)
11490YM-155
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YM-155 (chloride)

Item No. 36827

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,9-dihydro-3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium, monochloride
CAS Number
355406-09-6
Molecular Formula
C20H19N4O3 • Cl
Formula Weight
398.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: insolDMSO: insolEthanol: insolPBS (pH 7.2): 5 mg/ml
λmax
245, 252, 272 nm
SMILES
O=C1C2=C(C(C3=C1N(CCOC)C(C)=[N+]3CC4=NC=CN=C4)=O)C=CC=C2.[Cl-]
InChi Code
InChI=1S/C20H19N4O3.ClH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
InChi Key
NUZWGSASIPTGSA-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    YM-155 is a survivin inhibitor.1 It inhibits survivin promoter activity in a reporter assay (IC50 = 0.54 nM). YM-155 (10-1,000 nM) reduces survivin levels and induces apoptosis in PC3 and PPC-1 prostate cancer cells. In vivo, YM-155 (3 and 10 mg/kg) inhibits tumor growth, decreases intratumor survivin levels, and induces tumor regression in a PC3 mouse xenograft model. It reduces tumor volume in a MiaPaCa-2 pancreatic cancer mouse xenograft model.2 YM-155 also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) papain-like protease (PLpro; IC50 = 2.47 µM) and reduces the number of viral RNA copies in SARS-CoV-2-infected Vero E6 cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakahara, T., Takeuchi, M., Kinoyama, I., et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 67(17), 8014-8021 (2007).

    2. Na, Y.S., Yang, S.J., Kim, S.M., et al. YM155 induces EGFR suppression in pancreatic cancer cells. PLoS One 7(6), (2012).

    3. Zhao, Y., Du, X., Duan, Y., et al. High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein Cell 12(11), 877-888 (2021).