A P2Y14 receptor antagonist
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PPTN (hydrochloride)

Item No. 36854

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid, monohydrochloride
CAS Number
1992047-65-0
Molecular Formula
C29H24F3NO2 • HCl
Formula Weight
512.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
λmax
268 nm
SMILES
O=C(C1=CC2=CC(C3=CC=C(C(F)(F)F)C=C3)=CC=C2C(C4=CC=C(C5CCNCC5)C=C4)=C1)O.Cl
InChi Code
InChI=1S/C29H24F3NO2.ClH/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20;/h1-10,15-17,20,33H,11-14H2,(H,34,35);1H
InChi Key
FKMVYPCBLWYNAV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

    $196

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    10 mg

    $347

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    25 mg

    $758

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    Product Description

    PPTN is an antagonist of the purinergic P2Y14 receptor.1 It inhibits forskolin-induced cyclic AMP accumulation in C6 cells expressing human P2Y14 (EC50 = ~10 nM) but not CHO cells expressing P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 at 1 µM. PPTN (5 µM) inhibits UDP-glucose-induced IL-1β and chemokine (C-C motif) ligand 2 (CCL2) secretion, as well as ERK, JNK, and p38 MAPK phosphorylation in isolated rat satellite glial cells (SGCs).2 Trigeminal administration of PPTN (5 and 10 µM) reduces mechanical hyperalgesia induced by complete Freund’s adjuvant (CFA) in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barrett, M.O., Sesma, J.I., Ball, C.B., et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol. Pharmacol. 84(1), 41-49 (2013).

    2. Lin, J., Liu, F., Zhang, Y.-Y., et al. P2Y14 receptor is functionally expressed in satellite glial cells and mediates interleukin-1β and chemokine CCL2 secretion. J. Cell. Physiol. 234(11), 21199-21210 (2019).

    3. Lin, J., Zhang, Y.-Y., Liu, F., et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 131, 104567 (2019).