A peptide agonist of GLP-1R and an active metabolite of GLP-1 (7-36) amide
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GLP-1 (9-36) amide (trifluoroacetate salt)

Item No. 36863

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysylglycyl-L-argininamide, trifluoroacetate salt
Synonyms
  • Glucagon-like Peptide 1 (9-36) amide
Molecular Formula
C140H214N36O43 • XCF3COOH
Formula Weight
3089.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
EGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
N=C(N)NCCC[C@@H](C(N)=O)NC(CNC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC(CNC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@H](O)C)NC(CNC([C@@H](N)CCC(O)=O)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C140H214N36O43.C2HF3O2/c1-16-72(10)112(137(217)155-75(13)118(198)162-97(59-81-61-149-85-35-24-23-34-83(81)85)127(207)164-93(55-69(4)5)128(208)173-110(70(6)7)135(215)161-87(36-25-27-51-141)120(200)151-62-103(184)156-86(115(145)195)38-29-53-148-140(146)147)175-129(209)95(56-78-30-19-17-20-31-78)165-124(204)91(46-50-108(191)192)160-123(203)88(37-26-28-52-142)158-117(197)74(12)153-116(196)73(11)154-122(202)90(44-47-102(144)183)157-104(185)63-152-121(201)89(45-49-107(189)190)159-125(205)92(54-68(2)3)163-126(206)94(58-80-39-41-82(182)42-40-80)166-132(212)99(65-177)169-134(214)101(67-179)170-136(216)111(71(8)9)174-131(211)98(60-109(193)194)167-133(213)100(66-178)171-139(219)114(77(15)181)176-130(210)96(57-79-32-21-18-22-33-79)168-138(218)113(76(14)180)172-105(186)64-150-119(199)84(143)43-48-106(187)188;3-2(4,5)1(6)7/h17-24,30-35,39-42,61,68-77,84,86-101,110-114,149,177-182H,16,25-29,36-38,43-60,62-67,141-143H2,1-15H3,(H2,144,183)(H2,145,195)(H,150,199)(H,151,200)(H,152,201)(H,153,196)(H,154,202)(H,155,217)(H,156,184)(H,157,185)(H,158,197)(H,159,205)(H,160,203)(H,161,215)(H,162,198)(H,163,206)(H,164,207)(H,165,204)(H,166,212)(H,167,213)(H,168,218)(H,169,214)(H,170,216)(H,171,219)(H,172,186)(H,173,208)(H,174,211)(H,175,209)(H,176,210)(H,187,188)(H,189,190)(H,191,192)(H,193,194)(H4,146,147,148);(H,6,7)/t72-,73-,74-,75-,76+,77+,84-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,110-,111-,112-,113-,114-;/m0./s1
InChi Key
VYPASAXGAOYBFX-ADVUUXPKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Glucagon-like peptide 1 (GLP-1) (9-36) amide is a peptide agonist of the GLP-1 receptor (GLP-1R) and an active metabolite of GLP-1 (7-36) amide (Item No. 15069).1,2 It is formed from GLP-1 (7-36) by dipeptidyl peptidase 4 (DPP-4).2 GLP-1 (9-36) amide induces cAMP accumulation in a reporter assay using HEK293 cells expressing human GLP-1R (EC50 = 309.03 µM).1 It reduces blood glucose levels in pigs when infused at a concentration of 2.55 pmol/kg per minute.3 Infusion of GLP-1 (9-36) amide (1.5 pmol/kg per minute) decreases left ventricle systolic pressure and end-diastolic pressure and heart contractility and rate in a dog model of dilated cardiomyopathy.4 It increases mean arterial blood pressure, stroke volume, myocardial glucose uptake, and plasma norepinephrine levels in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, N., Lu, J., and Willars, G.B. Allosteric modulation of the activity of the glucagon-like peptide-1 (GLP-1) metabolite GLP-1 9-36 amide at the GLP-1 receptor. PLoS One 7(10), e47936 (2012).

    2. Deacon, C.F., Johnsen, A.H., and Holst, J.J. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J. Clin. Endocrinol. Metab. 80(3), 952-957 (1995).

    3. Deacon, C.F., Plamboeck, A., Møller, S., et al. GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion. Am. J. Physiol. Endocrinol. Metab. 282(4), E873-E879 (2002).

    4. Nikolaidis, L.A., Elahi, D., Shen, Y.-T., et al. Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy. Am. J. Physiol. Heart. Circ. Physiol. 289(6), H2401-H2408 (2005).