A peptide PAR1 agonist
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TRAP-6 amide (trifluoroacetate salt)

Item No. 36881

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-2-((2S,5S,8S,11S,14S)-14-amino-11-benzyl-2-(3-guanidinopropyl)-15-hydroxy-5,8-diisobutyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecanamido)succinamide
Synonyms
  • Ser-Phe-Leu-Leu-Arg-Asn-NH2
  • SFLLRN-NH2
  • Thrombin Receptor Agonist Peptide-6 amide
Molecular Formula
C34H57N11O8 • XCF3COOH
Formula Weight
747.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 12 mg/mLEthanol: Slightly solublePBS (pH 7.2): 5 mg/mL
SMILES
NC(C[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)CO)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C34H57N11O8.C2HF3O2/c1-18(2)13-24(31(51)41-22(11-8-12-40-34(38)39)30(50)42-23(28(37)48)16-27(36)47)44-32(52)25(14-19(3)4)45-33(53)26(43-29(49)21(35)17-46)15-20-9-6-5-7-10-20;3-2(4,5)1(6)7/h5-7,9-10,18-19,21-26,46H,8,11-17,35H2,1-4H3,(H2,36,47)(H2,37,48)(H,41,51)(H,42,50)(H,43,49)(H,44,52)(H,45,53)(H4,38,39,40);(H,6,7)/t21-,22-,23-,24-,25-,26-;/m0./s1
InChi Key
YICKZNIVMKPQPD-POCCEKOUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $86

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    10 mg

    $154

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    50 mg

    $598

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    100 mg

    $1,023

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    Cayman Chemical
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    Product Description

    TRAP-6 amide is a peptide agonist of proteinase-activated receptor 1 (PAR1).1 It induces platelet aggregation in vitro (EC50 = 0.15 µM). TRAP-6 amide (30 µM) induces relaxation of isolated guinea pig internal anal sphincter strips.2 It also increases cigarette smoke extract-induced IL-8 release from isolated human bronchial epithelial cells when used at a concentration of 50 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Elliott, J.T., Hoekstra, W.J., Derian, C.K., et al. Tritiated photoactivatable analogs of the native human thrombin receptor (PAR-1) agonist peptide, SFLLRN-NH2. J. Pept. Res. 57(6), 494-506 (2001).

    2. Huang, S.-C. Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincter. Regul. Pept. 189, 46-50 (2014).

    3. Montalbano, A.M., Chiappara, G., Albano, G.D., et al. Expression/activation of PAR-1 in airway epithelial cells of COPD patients: Ex vivo/in vitro study. Int. J. Mol. Sci. 22(19), 10703 (2021).