An ATGL inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

NG-497

Item No. 36886

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(4-ethoxyphenyl)-4-methoxy-2-pyridinecarboxylic acid, 1-methylethyl ester
CAS Number
2598242-66-9
Molecular Formula
C18H21NO4
Formula Weight
315.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 3 mg/ml
λmax
256, 282 nm
SMILES
O=C(C1=CC(OC)=CC(C2=CC=C(OCC)C=C2)=N1)OC(C)C
InChi Code
InChI=1S/C18H21NO4/c1-5-22-14-8-6-13(7-9-14)16-10-15(21-4)11-17(19-16)18(20)23-12(2)3/h6-12H,5H2,1-4H3
InChi Key
VYEIBLWRGBQRPI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $32

    Add

    5 mg

    $86

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    NG-497 is an inhibitor of adipose triglyceride lipase (ATGL; IC50 = 1 µM), also known as patatin-like phospholipase domain-containing protein 2 (PNPLA2).1 It is selective for ATGL over PNPLA1, PNPLA3, PNPLA4, and PNPLA5 at 100 µM. NG-497 selectively inhibits the triacylglycerol hydrolase activity of human and rhesus monkey ATGL over rat, dog, and marmoset ATGL, which it inhibits by less than 20% at 50 µM, and over mouse, goat, and pig ATGL at which it is inactive at 50 µM. NG-497 inhibits fatty acid and glycerol release induced by isoproterenol (Item No. 15592) in human Simpson-Golabi-Behmel syndrome (SGBS) adipocytes (IC50 = 1.5 µM for both). It also inhibits forskolin-induced fatty acid release in primary human adipocytes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grabner, G.F., Guttenberger, N., Mayer, N., et al. Small-molecule inhibitors targeting lipolysis in human adipocytes. J. Am. Chem. Soc. 144(14), 6237-6250 (2022).