A peptide substrate for Akt
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Crosstide (trifluoroacetate salt)

Item No. 36889

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-α-glutamyl-glycine, trifluoroacetate salt
Synonyms
  • Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH
  • GRPRTSSFAEG-OH
Molecular Formula
C48H77N17O17 • XCF3COOH
Formula Weight
1164.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
SMILES
N=C(N)NCCC[C@H](NC(CN)=O)C(N1[C@@H](CCC1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(NCC(O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C48H77N17O17.C2HF3O2/c1-24(38(74)59-28(14-15-35(70)71)39(75)56-21-36(72)73)57-41(77)30(19-26-9-4-3-5-10-26)61-42(78)31(22-66)62-43(79)32(23-67)63-45(81)37(25(2)68)64-40(76)27(11-6-16-54-47(50)51)60-44(80)33-13-8-18-65(33)46(82)29(58-34(69)20-49)12-7-17-55-48(52)53;3-2(4,5)1(6)7/h3-5,9-10,24-25,27-33,37,66-68H,6-8,11-23,49H2,1-2H3,(H,56,75)(H,57,77)(H,58,69)(H,59,74)(H,60,80)(H,61,78)(H,62,79)(H,63,81)(H,64,76)(H,70,71)(H,72,73)(H4,50,51,54)(H4,52,53,55);(H,6,7)/t24-,25+,27-,28-,29-,30-,31-,32-,33-,37-;/m0./s1
InChi Key
KBSHTPYYPODSQM-GCBPKDEWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Crosstide is a synthetic peptide substrate for Akt.1 It corresponds to the amino acid sequence of glycogen synthase kinase 3 (GSK3) that surrounds the serine residue phosphorylated by p90 ribosomal S6 kinase 1 (RSK1) or p70 ribosomal S6 kinase (p70S6K). Crosstide has been used in the study of Akt activity.1,2 It is also a substrate for serum/glucocorticoid-regulated kinase family member 3 (SGK3).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cross, D.A.E., Slessi, D.R., Cohen, P., et al. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378(6559), 785-789 (1995).

    2. Tanti, J.-F., Grillo, S., Gremeaux, T., et al. Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes. Endocrinology 138(5), 2005-2010 (1997).

    3. Dai, F., Yu, L., He, H., et al. Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3β) at serine-9 through direct interaction. Biochem. Biophys. Res. Commun. 293(4), 1191-1196 (2002).