An antimicrobial peptide
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Histatin 8 (trifluoroacetate salt)

Item No. 36891

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-phenylalanyl-L-histidyl-L-α-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginylglycyl-L-tyrosine, trifluoroacetate salt
Synonyms
  • Hst-8
Molecular Formula
C70H99N25O17 • XCF3COOH
Formula Weight
1562.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
KFHEKHHSHRGY-OH
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: Slightly solublePBS (pH 7.2): 10 mg/ml
SMILES
OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC(CNC([C@H](CCCNC(N)=N)NC([C@H](CC2=CN=CN2)NC([C@H](CO)NC([C@H](CC3=CN=CN3)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](N)CCCCN)=O)CC4=CC=CC=C4)=O)CC5=CN=CN5)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C70H99N25O17.C2HF3O2/c71-20-6-4-11-46(73)59(101)90-50(23-39-9-2-1-3-10-39)63(105)92-51(25-41-29-76-35-82-41)65(107)89-49(18-19-58(99)100)62(104)88-48(12-5-7-21-72)61(103)91-53(27-43-31-78-37-84-43)66(108)93-54(28-44-32-79-38-85-44)67(109)95-56(34-96)68(110)94-52(26-42-30-77-36-83-42)64(106)87-47(13-8-22-80-70(74)75)60(102)81-33-57(98)86-55(69(111)112)24-40-14-16-45(97)17-15-40;3-2(4,5)1(6)7/h1-3,9-10,14-17,29-32,35-38,46-56,96-97H,4-8,11-13,18-28,33-34,71-73H2,(H,76,82)(H,77,83)(H,78,84)(H,79,85)(H,81,102)(H,86,98)(H,87,106)(H,88,104)(H,89,107)(H,90,101)(H,91,103)(H,92,105)(H,93,108)(H,94,110)(H,95,109)(H,99,100)(H,111,112)(H4,74,75,80);(H,6,7)/t46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-;/m0./s1
InChi Key
BXTKIQIOPWOBEN-KMQSTWANSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Histatin 8 is a salivary antimicrobial peptide and proteolytic fragment of histatin 3 and histatin 5 (Item No. 36721).1 It is active against A. baumannii, including strains that are susceptible or resistant to colistin (Item No. 17584) when used at a concentration of 32 µg/ml. Histatin 8 is also active against C. albicans and C. tropicalis (MICs = 1 and 5 mg/ml, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Neshani, A., Sedighian, H., Mirhosseini, S.A., et al. Antimicrobial peptides as a promising treatment option against Acinetobacter baumannii infections. Microb. Pathog. 146, 104238 (2020).

    2. Matheson, S.M.G., Cheeptham, N., and Huttunen-Hennelly, H.E.K. Investigating the effects of hydrophobicity and charge on the therapeutic ability of the antimicrobial histatin 8 peptide for potential use in oral applications. Int. J. Biol. 5(2), 85-91 (2013).