A peptide substrate of PKC
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EGFR Peptide (human, mouse) (trifluoroacetate salt)

Item No. 36896

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-lysyl-L-arginyl-L-threonyl-L-leucyl-L-arginyl-L-arginyl-L-leucine, trifluoroacetate salt
Synonyms
  • Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
  • Epidermal Growth Factor Receptor Peptide
Molecular Formula
C46H91N21O10 • XCF3COOH
Formula Weight
1098.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
CC(C)C[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C46H91N21O10.C2HF3O2/c1-24(2)22-32(40(74)64-29(14-9-19-58-44(51)52)37(71)62-30(15-10-20-59-45(53)54)38(72)66-33(42(76)77)23-25(3)4)65-41(75)34(26(5)68)67-39(73)31(16-11-21-60-46(55)56)63-36(70)28(13-6-7-17-47)61-35(69)27(48)12-8-18-57-43(49)50;3-2(4,5)1(6)7/h24-34,68H,6-23,47-48H2,1-5H3,(H,61,69)(H,62,71)(H,63,70)(H,64,74)(H,65,75)(H,66,72)(H,67,73)(H,76,77)(H4,49,50,57)(H4,51,52,58)(H4,53,54,59)(H4,55,56,60);(H,6,7)/t26-,27+,28+,29+,30+,31+,32+,33+,34+;/m1./s1
InChi Key
IRLNJNVKRYCDBX-OBNWERDISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $219

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    1 mg

    $329

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    5 mg

    $1,095

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    Product Description

    EGFR peptide is a peptide substrate of PKC that corresponds to an amino acid sequence from the intracellular region of EGFR.1 It has been used to monitor PKC activity in primary bovine retinal endothelial cells. Unlike EGFR peptide (myristoylated) (Item No. 36897), EGFR peptide does not inhibit PKC when used at a concentration of 50 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, J.Y., Tajkahara, N., Gabriele, A., et al. Induction of endothelin-1 expression by glucose: An effect of protein kinase C activation. Diabetes 49(7), 1239-1248 (2000).

    2. O'Brian, C.A., Ward, N.E., Liskamp, R.M., et al. A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin. Invest. New Drugs 9(2), 169-179 (1991).