A PKC inhibitor
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EGFR Peptide (human, mouse) (myristoylated) (trifluoroacetate salt)

Item No. 36897

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tetradecanoyl-L-arginyl-L-lysyl-L-arginyl-L-threonyl-L-leucyl-L-arginyl-L-arginyl-L-leucine, trifluoroacetate salt
Synonyms
  • Epidermal Growth Factor Receptor Peptide
  • Myr-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
  • N-myristoyl-RKRTLRRL
Molecular Formula
C60H117N21O11 • XCF3COOH
Formula Weight
1308.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
Myr-RKRTLRRL-OH
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
CC(C)C[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C60H117N21O11.C2HF3O2/c1-7-8-9-10-11-12-13-14-15-16-17-29-47(83)74-40(25-20-31-70-57(62)63)49(84)75-41(24-18-19-30-61)50(85)77-44(28-23-34-73-60(68)69)53(88)81-48(39(6)82)55(90)79-45(35-37(2)3)54(89)78-42(26-21-32-71-58(64)65)51(86)76-43(27-22-33-72-59(66)67)52(87)80-46(56(91)92)36-38(4)5;3-2(4,5)1(6)7/h37-46,48,82H,7-36,61H2,1-6H3,(H,74,83)(H,75,84)(H,76,86)(H,77,85)(H,78,89)(H,79,90)(H,80,87)(H,81,88)(H,91,92)(H4,62,63,70)(H4,64,65,71)(H4,66,67,72)(H4,68,69,73);(H,6,7)/t39-,40+,41+,42+,43+,44+,45+,46+,48+;/m1./s1
InChi Key
SPCFEKUJOXLWHQ-KWHCAZBOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $103

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    50 mg

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    Product Description

    EGFR peptide (myristoylated) is a synthetic peptide inhibitor of PKC (IC50 = 5 µM) that corresponds to an amino acid sequence from the intracellular region of EGFR.1 It reverses resistance to doxorubicin (Item No. 15007) in doxorubicin-resistant UV-2237M (UV-2237M-ADRR) fibrosarcoma cells when used at a concentration of 1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. O'Brian, C.A., Ward, N.E., Liskamp, R.M., et al. A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin. Invest. New Drugs 9(2), 169-179 (1991).