An antimicrobial peptide
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Cecropin B (trifluoroacetate salt)

Item No. 36902

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl-L-lysyl-L-lysyl-L-isoleucyl-L-α-glutamyl-L-lysyl-L-methionylglycyl-L-arginyl-L-asparaginyl-L-isoleucyl-L-arginyl-L-asparaginylglycyl-L-isoleucyl-L-valyl-L-lysyl-L-alanylglycyl-L-prolyl-L-alanyl-L-isoleucyl-L-alanyl-L-valyl-L-leucylglycyl-L-α-glutamyl-L-alanyl-L-lysyl-L-alanyl-L-leucinamide, trifluoroacetate salt
Molecular Formula
C176H302N52O41S • XCF3COOH
Formula Weight
3834.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: insolDMSO: 3 mg/mlEthanol: insolPBS (pH 7.2): 3 mg/ml
SMILES
[H]NCCCC[C@H](NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CCCCN[H])N[H])=O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CCSC)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(NCC(N[C@@](C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@H](C(NCC(N3CCC[C@H]3C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(NCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)C)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)C)=O)([H])[C@H](CC)C)=O)C)=O)=O)=O)C)=O)=O)=O)([H])[C@H](CC)C)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)=O)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)=O)CC4=CC=CC=C4)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C176H302N52O41S.C2HF3O2/c1-25-97(15)140(174(269)224-139(96(13)14)168(263)212-113(57-36-43-72-179)155(250)199-101(19)145(240)198-91-134(234)228-79-50-64-128(228)167(262)202-104(22)149(244)225-141(98(16)26-2)171(266)203-105(23)148(243)222-137(94(9)10)169(264)219-123(82-93(7)8)152(247)196-89-132(232)205-119(65-67-135(235)236)156(251)201-102(20)146(241)206-112(56-35-42-71-178)154(249)200-103(21)147(242)215-122(144(187)239)81-92(5)6)221-133(233)90-197-153(248)126(85-129(185)229)217-160(255)118(63-49-78-193-176(190)191)213-172(267)143(100(18)28-4)227-166(261)127(86-130(186)230)218-157(252)111(62-48-77-192-175(188)189)204-131(231)88-195-151(246)121(69-80-270-24)211-159(254)114(58-37-44-73-180)207-161(256)120(66-68-136(237)238)214-173(268)142(99(17)27-3)226-163(258)117(61-40-47-76-183)208-158(253)115(59-38-45-74-181)209-164(259)124(83-106-51-30-29-31-52-106)220-170(265)138(95(11)12)223-162(257)116(60-39-46-75-182)210-165(260)125(216-150(245)109(184)54-34-41-70-177)84-107-87-194-110-55-33-32-53-108(107)110;3-2(4,5)1(6)7/h29-33,51-53,55,87,92-105,109,111-128,137-143,194H,25-28,34-50,54,56-86,88-91,177-184H2,1-24H3,(H2,185,229)(H2,186,230)(H2,187,239)(H,195,246)(H,196,247)(H,197,248)(H,198,240)(H,199,250)(H,200,249)(H,201,251)(H,202,262)(H,203,266)(H,204,231)(H,205,232)(H,206,241)(H,207,256)(H,208,253)(H,209,259)(H,210,260)(H,211,254)(H,212,263)(H,213,267)(H,214,268)(H,215,242)(H,216,245)(H,217,255)(H,218,252)(H,219,264)(H,220,265)(H,221,233)(H,222,243)(H,223,257)(H,224,269)(H,225,244)(H,226,258)(H,227,261)(H,235,236)(H,237,238)(H4,188,189,192)(H4,190,191,193);(H,6,7)/t97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,137-,138-,139-,140-,141-,142-,143-;/m0./s1
InChi Key
VWTUEJAIDBXHIK-JAGWGCJLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Cecropin B is an antimicrobial peptide.1 It is active against the Gram-positive bacteria S. aureus, B. subtilis, Sporosarcina, and Curtobacterium (MICs = 0.89, 0.98, 0.88, and 0.97 µM, respectively) and the Gram-negative bacteria E. coli, S. pullorum, and P. aeruginosa (MICs = 0.5, 0.78, and 0.98, respectively). Cecropin B also induces membrane permeabilization in, and is active against the plant pathogenic fungi R. solani (MIC = 9.8 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, X., Zhu, M., Yang, G., et al. Expression of cecropin B in Pichia pastoris and its bioactivity in vitro. Exp. Ther. Med. 2(4), 655-660 (2011).

    2. Oard, S., Rush, M.C., and Oard, J.H. Characterization of antimicrobial peptides against a US strain of the rice pathogen Rhizoctonia solani. J. Appl. Microbiol. 97(1), 169-180 (2004).