An EphA4 inhibitor
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KYL (trifluoroacetate salt)

Item No. 36911

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-tyrosyl-L-leucyl-L-prolyl-L-tyrosyl-L-tryptophyl-L-prolyl-L-valyl-L-leucyl-L-seryl-L-seryl-L-leucine, trifluoroacetate salt
Synonyms
  • KYL Peptide
Molecular Formula
C74H108N14O17 • XCF3COOH
Formula Weight
1465.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 14 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.30 mg/ml
SMILES
O=C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC2=CC=C(C=C2)O)NC([C@H]3N(CCC3)C([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)CCCCN)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C74H108N14O17.C2HF3O2/c1-40(2)31-52(64(94)84-59(39-90)68(98)85-58(38-89)67(97)83-57(74(104)105)33-42(5)6)80-71(101)62(43(7)8)86-70(100)61-19-14-30-88(61)73(103)56(36-46-37-77-51-17-10-9-15-49(46)51)82-66(96)54(35-45-22-26-48(92)27-23-45)79-69(99)60-18-13-29-87(60)72(102)55(32-41(3)4)81-65(95)53(34-44-20-24-47(91)25-21-44)78-63(93)50(76)16-11-12-28-75;3-2(4,5)1(6)7/h9-10,15,17,20-27,37,40-43,50,52-62,77,89-92H,11-14,16,18-19,28-36,38-39,75-76H2,1-8H3,(H,78,93)(H,79,99)(H,80,101)(H,81,95)(H,82,96)(H,83,97)(H,84,94)(H,85,98)(H,86,100)(H,104,105);(H,6,7)/t50-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-;/m0./s1
InChi Key
YYPCRGKMMQIWHY-RASRAIPSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    KYL is a 12-amino acid synthetic peptide and an inhibitor of the Eph tyrosine kinase receptor A4 (EphA4; IC50 = 4.22 µM).1 KYL inhibits EphA4-induced growth cone collapse in embryonic chicken retina explants when used at a concentration of 5 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, B., Zhang, Z., Noberini, R., et al. HTS by NMR of combinatorial libraries: A fragment-based approach to ligand discovery. Chem. Biol. 20(1), 19-33 (2013).

    2. Noberini, R., Koolpe, M., Peddibhotla, S., et al. Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors. The Journal of Biological Chemisty 283(43), 29461-29472 (2008).