A GLP-1R agonist and active metabolite of exendin-4 (48-86) amide
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Parent Compound(s)
11096Exendin-4 amide (acetate)
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Exendin-4 (3-39) amide (trifluoroacetate salt)

Item No. 36912

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide, trifluoroacetate salt
Synonyms
  • Exendin (3-39)
Molecular Formula
C176H272N46O58S • XCF3COOH
Formula Weight
3992.4
Purity
≥90%
Formulation (Request formulation change)
A solid
Peptide Sequence
EGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
Solubility(Learn about Variance in Solubility)
Methanol: SolubleWater: Soluble
SMILES
OC(C(F)(F)F)=O.OC(C[C@H](NC([C@H](CO)NC([C@]([H])([C@@H](C)O)NC([C@@H](NC([C@]([H])([C@@H](C)O)NC(CNC([C@H](CCC(O)=O)N[H])=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCCN[H])C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CC(N)=O)C(NCC(NCC(N4CCC[C@H]4C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@H](C(N5CCC[C@H]5C(N6CCC[C@H]6C(N7CCC[C@H]7C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)([H])[C@H](CC)C)=O)CC8=CC=CC=C8)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O
InChi Code
InChI=1S/C176H272N46O58S.C2HF3O2/c1-16-90(10)140(170(275)201-108(52-58-137(244)245)155(260)206-115(73-97-76-186-100-39-24-23-38-98(97)100)160(265)203-110(68-86(2)3)157(262)193-102(41-26-28-61-178)150(255)207-116(74-128(181)231)146(251)189-77-129(232)187-80-132(235)219-63-30-43-123(219)167(272)213-121(84-226)166(271)211-119(82-224)147(252)190-78-130(233)191-92(12)173(278)221-65-32-45-125(221)175(280)222-66-33-46-126(222)174(279)220-64-31-44-124(220)168(273)210-118(81-223)143(182)248)217-162(267)113(71-95-34-19-17-20-35-95)205-158(263)111(69-87(4)5)202-151(256)103(42-29-62-185-176(183)184)200-169(274)139(89(8)9)216-144(249)91(11)192-148(253)105(49-55-134(238)239)196-153(258)106(50-56-135(240)241)197-154(259)107(51-57-136(242)243)198-156(261)109(59-67-281-15)199-152(257)104(48-53-127(180)230)195-149(254)101(40-25-27-60-177)194-164(269)120(83-225)212-159(264)112(70-88(6)7)204-161(266)117(75-138(246)247)208-165(270)122(85-227)214-172(277)142(94(14)229)218-163(268)114(72-96-36-21-18-22-37-96)209-171(276)141(93(13)228)215-131(234)79-188-145(250)99(179)47-54-133(236)237;3-2(4,5)1(6)7/h17-24,34-39,76,86-94,99,101-126,139-142,186,223-229H,16,25-33,40-75,77-85,177-179H2,1-15H3,(H2,180,230)(H2,181,231)(H2,182,248)(H,187,232)(H,188,250)(H,189,251)(H,190,252)(H,191,233)(H,192,253)(H,193,262)(H,194,269)(H,195,254)(H,196,258)(H,197,259)(H,198,261)(H,199,257)(H,200,274)(H,201,275)(H,202,256)(H,203,265)(H,204,266)(H,205,263)(H,206,260)(H,207,255)(H,208,270)(H,209,276)(H,210,273)(H,211,271)(H,212,264)(H,213,272)(H,214,277)(H,215,234)(H,216,249)(H,217,267)(H,218,268)(H,236,237)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H4,183,184,185);(H,6,7)/t90-,91-,92-,93+,94+,99-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,139-,140-,141-,142-;/m0./s1
InChi Key
KGMYYEONFAMZOW-BNSREOSNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Exendin-4 (3-39) amide is an agonist of glucagon-like peptide 1 receptor (GLP-1R) and an active metabolite of exendin-4 (48-86) amide (Item No. 11096).1,2 It is formed from exendin-4 (48-86) amide in rat liver homogenates.2 Exendin-4 (3-39) amide induces cAMP accumulation in HEK293 cells expressing human GLP-1R (EC50 = 9 nM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patterson, J.T., Ottaway, N., Gelfanov, V.M., et al. A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1. ACS Chem. Biol. 6(2), 135-145 (2011).

    2. Liao, S., Liang, Y., Zhang, Z., et al. In vitro metabolic stability of exendin-4: Pharmacokinetics and identification of cleavage products. PLoS One 10(2), e0116805 (2015).