A resuscitative agent
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Centhaquin

Item No. 36929

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-[4-(3-methylphenyl)-1-piperazinyl]ethyl]-quinoline
CAS Number
57961-90-7
Synonyms
  • Centhaquine
  • PMZ-2010
Molecular Formula
C22H25N3
Formula Weight
331.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/ml
λmax
227 nm
SMILES
CC1=CC(N(CC2)CCN2CCC3=NC4=C(C=C3)C=CC=C4)=CC=C1
InChi Code
InChI=1S/C22H25N3/c1-18-5-4-7-21(17-18)25-15-13-24(14-16-25)12-11-20-10-9-19-6-2-3-8-22(19)23-20/h2-10,17H,11-16H2,1H3
InChi Key
UJNWGFBJUHIJKK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Centhaquin is a resuscitative agent.1 It binds to serotonin (5-HT) receptors in isolated rat cerebral cortex and brainstem membranes (Kis = 178.9 and 103.7 nM, respectively).2 Centhaquin (0.05-0.45 mg/kg) increases the latency to tail-flick in mice, an effect that can be reversed by the α2A-adenergic receptor (α2A-AR) antagonist BRL 44408 (Item No. 29454) and α2B-AR antagonist imiloxan but not the α2C-AR antagonist JP-1302 (Item No. 25974).3 It increases mean arterial blood pressure (MAP), cardiac output, and survival following bleeding-induced hypotension in a rat model of hemorrhagic shock when administered at doses ranging from 0.006 to 0.05 mg/kg in combination with hypertonic saline.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gulati, A., Lavhale, M.S., Garcia, D.J., et al. Centhaquin improves resuscitative effect of hypertonic saline in hemorrhaged rats. J. Surg. Res. 178(1), 415-423 (2012).

    2. Gulati, A., Arora, R.C., and Crayton, J. Central serotonergic uptake mechanisms in hypertensive rats: Effects of clonidine and centhaquin. Eur. J. Pharmacol. 231(2), 151-156 (1993).

    3. Bhalla, S., Ali, I., Andurkar, S.V., et al. Centhaquin antinociception in mice is mediated by α2A- and α2B- but not α2C-adrenoceptors. Eur. J. Pharmacol. 715(1-3), 328-336 (2013).