A lipidoid derivative of lithocholic acid
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LC10

Item No. 37000

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,5β)-N-[2-(didecylamino)ethyl]-3-hydroxy-cholan-24-amide
CAS Number
2768690-22-6
Molecular Formula
C46H86N2O2
Formula Weight
699.2
Purity
≥98%
Formulation (Request formulation change)
A 100 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 100 mg/ml
SMILES
C[C@H](CCC(NCCN(CCCCCCCCCC)CCCCCCCCCC)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C46H86N2O2/c1-6-8-10-12-14-16-18-20-33-48(34-21-19-17-15-13-11-9-7-2)35-32-47-44(50)27-22-37(3)41-25-26-42-40-24-23-38-36-39(49)28-30-45(38,4)43(40)29-31-46(41,42)5/h37-43,49H,6-36H2,1-5H3,(H,47,50)/t37-,38-,39-,40+,41-,42+,43+,45+,46-/m1/s1
InChi Key
IMZLXNOWENPGLY-RPXZJJFJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $74

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    10 mg

    $104

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    25 mg

    $239

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    Cayman Chemical
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    Product Description

    LC10 is a lipidoid derivative of the secondary bile acid lithocholic acid (Item No. 20253) that contains two 10-carbon alkyl chains.1 It has been used in the generation of self-assembling skin-permeable lipid nanoparticles (LNPs). LC10 LNPs inhibit the proliferation of normal human epidermal keratinocytes (NHEKs) when used at a concentration of 100 nM and reduce the levels of TNF-α, IL-17, and IL-23 in human peripheral blood mononuclear cells (PBMCs) at 50, 100, and 200 nM. Topical application of LC10 LNPs (10 mg/kg) reduces psoriatic-like plaques and reverses weight loss induced by imiquimod (Item No. 14956) in a mouse model of psoriasis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rachamalla, H.K., Voshavar, C., Arjunan, P., et al. Skin-permeable nano-lithocholic lipidoid efficiently alleviates psoriasis-like chronic skin inflammations. ACS Appl. Mater. Interfaces 14(13), 14859-14870 (2022).