FABP6 Rabbit Monoclonal Antibody (Clone 201)

Fatty acid-binding protein 6 (FABP6) is a member of the intracellular lipid-binding protein (iLBP) family with a role in bile acid homeostasis.^1,2 It is composed of 10 antiparallel β-strands, which form a β-barrel containing a lipid binding site and is expressed primarily in enterocytes of the ileum, and to a lesser extent in the adrenal gland, ovaries, and stomach.^3,4,1 FABP6 binds bile acids and fatty acids and interacts with the ileal bile acid transporter to aid in bile acid uptake and facilitate intracellular trafficking of bile acids.¹ Fabp6 knockdown induces dietary fat malabsorption, decreased bile acid reabsorption, and a sex-specific increase in adiposity in mice fed a Western diet.⁵ Serum levels of FABP6 are increased in patients with colorectal cancer and decrease following surgical removal of cancerous tissues.⁶ FABP6^T79M is associated with a decreased risk of type 2 diabetes in obese individuals.⁷ Cayman’s FABP6 Rabbit Monoclonal Antibody (Clone 201) can be used for flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications.

WARNING This product is not for human or veterinary use.

1. Smathers, R.L., and Petersen, D.R. The human fatty acid-binding protein family: Evolutionary divergences and functions. Hum. Genomics 5(3), 170-191 (2011).

2. Hendrick, A.G., Müller, I., Willems, H., et al. Identification and investigation of novel binding fragments in the fatty acid binding protein 6 (FABP6). J. Med. Chem. 59(17), 8094-8102 (2016).

3. Storch, J., and McDermott, L. Structural and functional analysis of fatty acid-binding proteins. J. Lipid Res. 50 Suppl(Suppl), S126-S131 (2009).

4. Kim, K., Cistola, D.P., and Frieden, C. Intestinal fatty acid-binding protein: The structure and stability of a helix-less variant. Biochemistry 35(23), 7553-7558 (1996).

5. Habib, S.M., Zwicker, B.L., Wykes, L., et al. Sexually dimorphic response of mice to the Western-style diet caused by deficiency of fatty acid binding protein 6 (Fabp6). Physiol. Rep. 9(3), e14733 (2021).

6. Zhang, Y., Zhao, X., Deng, L., et al. High expression of FABP4 and FABP6 in patients with colorectal cancer. World J. Surg. Oncol. 17(1), 171 (2019).

7. Fisher, E., Grallert, H., Klapper, M., et al. Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals. Mol. Genet. Metab. 98(4), 400-405 (2009).