For immunochemical detection of TG2
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Transglutaminase 2 Rabbit Monoclonal Antibody (Clone 013)

Item No. 37090

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • TG2
  • TGase 2
  • TGM2
  • Tissue Transglutaminase 2
Immunogen
Recombinant human TG2
Clone Designation
013
Formulation (Request formulation change)
50 or 100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
0.2 μm filtered solution in PBS
Host
Rabbit
Isotype
IgG
Applications
ELISA
Cross Reactivity
(+) TG2
Species Reactivity
(+) Human
UniProt Accession №
P21980
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    50 µl

    $145

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    100 µl

    $246

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    Cayman Chemical
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    Product Description

    Transglutaminase 2 (TG2) is a calcium-dependent enzyme that is involved in a variety of biological activities.1,2 TG2 is composed of an N-terminal β sandwich containing integrin and fibronectin binding sites, a catalytic domain, a guanine nucleotide-binding site, and two C-terminal β-barrel domains.1 It is ubiquitously expressed and is localized to the cytosol, cytoskeleton, endoplasmic reticulum, mitochondria, nucleus, cell surface, and extracellular space in a context-dependent manner.3 TG2 catalyzes post-translational modifications of proteins via inter- or intramolecular crosslinking of glutamine and lysine residues or transamidation of glutamine residues with polyamines such as spermidine (Item No. 14918).1,2 It also exhibits calcium-independent enzyme activities, including GTPase, protein kinase, and disulfide isomerase activities, and binds to several cell surface adhesion molecules in the extracellular matrix (ECM).1,4 TG2 acts on a wide variety of protein substrates that have roles in neurological, autoimmune, and metabolic diseases, as well as carcinogenesis. Cayman’s Transglutaminase 2 Rabbit Monoclonal Antibody (Clone 013) can be used for ELISA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Odii, B.O., and Coussons, P. Biological functionalities of transglutaminase 2 and the possibility of its compensation by other members of the transglutaminase family. ScientificWorldJournal 714561, (2014).

    2. Porta, R., Esposito, C., Metafora, S., et al. Mass spectrometric identification of the amino donor and acceptor sites in a transglutaminase protein substrate secreted from rat seminal vesicles. Biochemistry 30(12), 3114-3120 (1991).

    3. Piacentini, M., D'Eletto, M., Farrace, M.G., et al. Characterization of distinct sub-cellular location of transglutaminase type II: Changes in intracellular distribution in physiological and pathological states. Cell Tissue Res. 358(3), 793-805 (2014).

    4. Belkin, A.M. Extracellular TG2: Emerging functions and regulation. FEBS J. 278(24), 4704-4716 (2011).