A metabolite produced by various gut microbiota
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δ-Valerobetaine

Item No. 37092

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-carboxy-N,N,N-trimethyl-1-butanaminium, inner salt
CAS Number
6778-33-2
Synonyms
  • δ-Aminovaleric Acid Betaine
Molecular Formula
C8H17NO2
Formula Weight
159.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(CCCC[N+](C)(C)C)[O-]
InChi Code
InChI=1S/C8H17NO2/c1-9(2,3)7-5-4-6-8(10)11/h4-7H2,1-3H3
InChi Key
CDLVFVFTRQPQFU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $65

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    1 mg

    $124

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    5 mg

    $260

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    δ-Valerobetaine is a metabolite produced by various gut microbiota, including S. typhimurium, B. longum, and lactobacilli.1 It reduces the palmitate-dependent oxygen consumption rate (OCR) in glucose-, glutamine-, and pyruvate-deprived HepG2 cells when used at concentrations of 10 and 50 µM. In vivo, δ-valerobetaine (10 and 100 mg/kg) decreases hepatic mitochondrial long-chain acylcarnitine levels and enhances hepatic steatosis in fasted, but not fed, mice. It also increases visceral adipose tissue (VAT), brown adipose tissue (BAT), and subcutaneous white adipose tissue (WAT) weights in germ-free and conventional mice fed a Western diet. Plasma levels of δ-valerobetaine are positively correlated with visceral adipose tissue mass in humans.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, K.H., Owens, J.A., Saeedi, B., et al. Microbial metabolite delta-valerobetaine is a diet-dependent obesogen. Nat. Metab. 3(12), 1694-1705 (2021).