An anionic fluorescent probe for the conformational state of proteins
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2-p-Toluidinylnaphthylene-6-sulfonate (sodium salt)

Item No. 37140

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[(4-methylphenyl)amino]-2-naphthalenesulfonic acid, monosodium salt
CAS Number
53313-85-2
Synonyms
  • 6-(p-Toluidino)-2-naphthalenesulfonic Acid
  • TNS
Molecular Formula
C17H14NO3S • Na
Formula Weight
335.4
Purity
≥98%
Emission
446 nm
Excitation
321 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Slightly soluble
λmax
225, 274, 318 nm
SMILES
O=S([O-])(C1=CC=C2C=C(NC3=CC=C(C)C=C3)C=CC2=C1)=O.[Na+]
InChi Code
InChI=1S/C17H15NO3S.Na/c1-12-2-6-15(7-3-12)18-16-8-4-14-11-17(22(19,20)21)9-5-13(14)10-16;/h2-11,18H,1H3,(H,19,20,21);/q;+1/p-1
InChi Key
QZZGQOXRGFDEJP-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Product Description

    2-p-Toluidinylnaphthylene-6-sulfonate (TNS) is a fluorescent probe for the conformational state of proteins.1,2 Upon binding to the hydrophobic surface of proteins, TNS displays excitation and emission maxima of 321 and 446 nm, respectively. It has also been used to determine the pKa values of lipid nanoparticles (LNPs).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McClure, W.O., and Edelman, G.M. Fluorescent probes for conformational states of proteins. II. The binding of 2-p-toluidinylnaphthalene-6-sulfonate to alpha-chymotrypsin. Biochemistry 6(2), 559-566 (1967).

    2. Cócera, M., López, O., Estelrich, J., et al. Use of a fluorescence spectroscopy technique to study the adsorption of sodium dodecylsulfonate on liposomes. Chem. Phys. Lipids 110(1), 19-26 (2001).

    3. Carrasco, M.J., Alishetta, S., Alameh, M.-G., et al. Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration. Commun. Biol. 4(1), 956 (2021).