An Hb-O2 stabilizer
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Product Categories

Product Type

Biochemicals

Research Area

Cardiovascular System
Blood
Erythrocytes & Hemoglobin

Velaresol

Item No. 37190

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(2-formyl-3-hydroxyphenoxy)-pentanoic acid
CAS Number
77858-21-0
Synonyms
  • BW 12C
  • BW 12C79
Molecular Formula
C12H14O5
Formula Weight
238.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 10 mg/mlEthanol: Slightly soluble
SMILES
O=CC1=C(OCCCCC(O)=O)C=CC=C1O
InChi Code
InChI=1S/C12H14O5/c13-8-9-10(14)4-3-5-11(9)17-7-2-1-6-12(15)16/h3-5,8,14H,1-2,6-7H2,(H,15,16)
InChi Key
NSUDGNLOXMLAEB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $87

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    25 mg

    $194

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    50 mg

    $339

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    Product Description

    Velaresol is an oxyhemoglobin (Hb-O2) stabilizer.1 It increases erythrocyte deformability in isolated human blood from a patient with sickle cell disease when used at a concentration of 1.5 mM. Velaresol (3 or 5 mM) inhibits deoxygenation-induced decreases in erythrocyte deformability in isolated human blood from a patient with sickle cell disease. It decreases oxygen tension and increases oxygen saturation of isolated human sickle erythrocytes when used at a concentration of 5 mM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kenny, M.W., and Stuart, J. Preservation of deformability (filterability) of sickle cells by BW12C during progressive deoxygenation. Br. J. Haematol. 55(3), 465-471 (1983).

    2. Gibson, J.S., Khan, A., Speake, P.F., et al. O2 dependence of K+ transport in sickle cells: The effect of different cell populations and the substituted benzaldehyde 12C79. The FASEB Journal 15(3), 823-832 (2001).