MPO-IN-28

MPO-IN-28 is an adenosine A_2B receptor antagonist (K_i = 2.15 µM in HEK293 cells expressing the human receptor).¹ MPO-IN-28 is also a neuropeptide Y-like receptor 7 (NPYLR7) agonist, inducing calcium mobilization in HEK293T human kidney cells expressing mosquito (A. aegypti) NPYLR7 receptors in a reporter assay when used at a concentration of 10 µM.² It inhibits blood-feeding behavior in A. aegypti mosquitos after dietary administration when used at a concentration of 100 µM. MPO-IN-28 also has been used as a synthetic intermediate in the synthesis of Gram-positive bacterial DNA polymerase III inhibitors with antibacterial activity.³

WARNING This product is not for human or veterinary use.

1. Webb, T.R., Lvovskiy, D., Kim, S.-A., et al. Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2B receptors. Bioorg. Med. Chem. 11(1), 77-85 (2003).

2. Duvall, L.B., Ramos-Espiritu, L., Barsoum, K.E., et al. Small-molecule agonists of Ae. aegypti neuropeptide Y receptor block mosquito biting. Cell 176(4), 687-701 (2019).

3. Guiles, J., Sun, X., Critchley, I.A., et al. Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III. Bioorg. Med. Chem. Lett. 19(3), 800-802 (2009).