5-Aminosalicylic Acid-d₇

5-Aminosalicylic acid-d₇ (5-ASA-d₇) is intended for use as an internal standard for the quantification of 5-ASA (Item No. 70265) by GC- or LC-MS. 5-ASA is a non-steroidal anti-inflammatory drug (NSAID) and an active metabolite of sulphasalazine (Item No. 15025), basalazide (Item No. 18680), and olsalazine (Item No. 23661).¹ It selectively inhibits COX-2 over COX-1 in isolated human whole blood (IC₅₀s = 61 and 410 µM, respectively). 5-ASA inhibits hemoglobin- and hydrogen peroxide-induced lipid peroxidation in a cell-free assay (IC₅₀ = 50 µM).² It also inhibits the synthesis of leukotriene B₄ (LTB₄; Item No. 20110) in isolated human mucosal cells when used at a concentration of 100 µM.³ Formulations containing 5-ASA have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.

WARNING This product is not for human or veterinary use.

1. Warner, T.D., Giuliano, F., Vojnovic, I., et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proc. Natl. Acad. Sci. USA 96(13), 7563-7568 (1999).

2. Beiranvand, M. A review of the biological and pharmacological activities of mesalazine or 5-aminosalicylic acid (5-ASA): An anti-ulcer and anti-oxidant drug. Inflammopharmacology 29(5), 1279-1290 (2021).

3. Schmidt, C., Fels, T., Baumeister, B., et al. The effect of 5-aminosalicylate and para-aminosalicylate on the synthesis of prostaglandin E₂ and leukotriene B₄ in isolated colonic mucosal cells. Curr. Med. Res. Opin. 13(7), 417-425 (1996).