A prodrug form of 5-aminosalicylic acid
Related Products
Active Metabolite(s)
702655-Aminosalicylic Acid
Labeled Version(s)
33798Olsalazine-13C6
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Olsalazine (sodium salt)

Item No. 23661

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3'-(1,2-diazenediyl)bis[6-hydroxy-benzoic acid, disodium salt
CAS Number
6054-98-4
Synonyms
  • C.I. 14130
Molecular Formula
C14H8N2O6 • 2Na
Formula Weight
346.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 2 mg/ml
λmax
219, 253, 362 nm
SMILES
[O-]C(C1=C(O)C=CC(/N=N/C2=CC=C(O)C(C([O-])=O)=C2)=C1)=O.[Na+].[Na+]
InChi Code
InChI=1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,17-18H,(H,19,20)(H,21,22);;/q;2*+1/p-2/b16-15+;;
InChi Key
ZJEFYLVGGFISGT-VRZXRVJBSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    250 mg

    $54

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    500 mg

    $102

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    1 g

    $190

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    5 g

    $834

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    Product Description

    Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (5-ASA; Item No. 70265) that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1 In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50 = 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of 5 mM.2,3 Olsalazine (150 mg/kg for 8 days) improves stool consistency and decreases occult and gross bleeding as well as myeloperoxidase (MPO) activity and leukotriene B4 (LTB4; Item No. 20110) levels in colon tissue in a mouse model of acute colitis induced by dextran sulfate (Item No. 23250).4 Olsalazine also inhibits bovine xanthine oxidase in vitro (IC50 = 3.4 mg/L) and lowers serum uric acid levels in a mouse model of hyperuricemia induced by oxonic acid (Item No. 22586) when administered at a dose of 20 mg/kg.5 Formulations containing olsalazine have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nugent, S.G., Kumar, D., Rampton, D.S., et al. Intestinal luminal pH in inflammatory bowel disease: Possible determinants and implications for therapy with aminosalicylates and other drugs. Gut 48(4), 571-577 (2001).

    2. Pamukcu, R., Hanauer, S.B., and Chang, E.B. Effect of disodium azodisalicylate on electrolyte transport in rabbit ileum and colon in vitro. Comparison with sulfasalazine and 5-aminosalicylic acid. Gastroenterology 95(4), 975-981 (1988).

    3. Mohsen, A.Q.M., Mulvey, D., Priddle, J.D., et al. Effects of olsalazine in the jejunum of the rat. Gut 28(3), 346-352 (1987).

    4. Murthy, S., Murthy, N.S., Coppola, D., et al. The efficacy of BAY y 1015 in dextran sulfate model of mouse colitis. Inflamm. Res. 46(6), 224-233 (1997).

    5. Niu, Y., Li, H., Gao, L., et al. Old drug, new indication: Olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity. J. Pharmacol. Sci. 135(3), 114-120 (2017).