A perfluoroalkyl substance
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Heptafluorobutyric Acid

Item No. 37234

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2,3,3,4,4,4-heptafluoro-butanoic acid
CAS Number
375-22-4
Synonyms
  • HFBA
  • Perfluorobutanoic Acid
  • Perfluorobutyric Acid
  • PFBA
  • NSC 820
Molecular Formula
C4HF7O2
Formula Weight
214.0
Purity
≥80%
Formulation
A neat oil
Solubility(Learn about Variance in Solubility)
Chloroform: solubleMethanol: soluble
SMILES
O=C(C(F)(C(F)(C(F)(F)F)F)F)O
InChi Code
InChI=1S/C4HF7O2/c5-2(6,1(12)13)3(7,8)4(9,10)11/h(H,12,13)
InChi Key
YPJUNDFVDDCYIH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $32

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    50 g

    $94

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    100 g

    $141

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    Cayman Chemical
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    Product Description

    Heptafluorobutyric acid is a perfluoroalkyl substance (PFAS).1 Chronic topical administration of heptafluorobutyric acid (25 µl of a 3.75-15% v/v solution) on the ear increases liver and kidney weight in mice. It induces multifocal hepatocyte necrosis and centrilobular hepatocyte hypertrophy when administered topically at a concentration of 7.5% v/v. Heptafluorobutyric acid (15% v/v) increases serum cholesterol and alkaline phosphatase (ALP) levels and decreases serum urea nitrogen levels. It has been found in marine life and as a contaminant in surface water.2,3 Formulations containing heptafluorobutyric acid have been used as ion pair reagents for reverse-phase HPLC and in the synthesis and solubilization of proteins and peptides.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Weatherly, L.M., Shane, H.L., Lukomska, E., et al. Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model. Food Chem. Toxicol. 156, 112528 (2021).

    2. Lemos, L., Gantiva, L., Kaylor, C., et al. American oysters as bioindicators of emerging organic contaminants in Florida, United States. Sci. Total Environ. 835, 155316 (2022).

    3. Li, Q., Wang, P., Wang, C., et al. A novel procedure for predicting chronic toxicities and ecological risks of perfluorinated compounds in aquatic environment. Environ. Res. 215(Pt 1), 114132 (2022).