An inhibitor of HDAC6
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SKLB23bb

Item No. 37242

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-hydroxy-4-[2-methoxy-5-[methyl(2-methyl-4-quinazolinyl)amino]phenoxy]-butanamide
CAS Number
1815580-06-3
Molecular Formula
C21H24N4O4
Formula Weight
396.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(CCCOC1=CC(N(C)C2=NC(C)=NC3=C2C=CC=C3)=CC=C1OC)NO
InChi Code
InChI=1S/C21H24N4O4/c1-14-22-17-8-5-4-7-16(17)21(23-14)25(2)15-10-11-18(28-3)19(13-15)29-12-6-9-20(26)24-27/h4-5,7-8,10-11,13,27H,6,9,12H2,1-3H3,(H,24,26)
InChi Key
FWXZZFONXWYSEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $203

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    Product Description

    SKLB23bb is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 17 nM).1 It is selective for HDAC6 over HDAC1-5 and HDAC7-11 (IC50s = 386->10,000 nM). SKLB23bb inhibits tubulin acetylation in HeLa cervical cancer cells (EC50 = 58.9 nM) and the proliferation of A375 melanoma and HeLa cells (IC50s = 45 and 49 nM, respectively). It also binds to the colchicine site in β-tubulin and inhibits microtubule formation in MDA-MB-231 cells.2 In vivo, SKLB23bb (12.5-50 mg/kg) reduces tumor growth in HCT116, A2780, and MCF-7 mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, Z., T., W., Wang, F., et al. Discovery of selective histone deacetylase 6 inhibitors using the quinazoline as the cap for the treatment of cancer. J. Med. Chem. 59(4), 1455-1470 (2015).

    2. Wang, F., Zheng, L., Yi, Y., et al. SKLB-23bb, A HDAC6-selective inhibitor, exhibits superior and broad-spectrum antitumor activity via additionally targeting microtubules. Mol. Cancer Ther. 17(4), 763-775 (2018).