A perfluoroalkyl substance
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Perfluorononanoic Acid

Item No. 37250

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluoro-nonanoic acid
CAS Number
375-95-1
Synonyms
  • HDFNA
  • Heptadecafluorononanoic Acid
  • Perfluoropelargonic Acid
  • PFNA
Molecular Formula
C9HF17O2
Formula Weight
464.1
Purity
≥90%
Formulation
A low-melting solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
O=C(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)F)F)F)F)O
InChi Code
InChI=1S/C9HF17O2/c10-2(11,1(27)28)3(12,13)4(14,15)5(16,17)6(18,19)7(20,21)8(22,23)9(24,25)26/h(H,27,28)
InChi Key
UZUFPBIDKMEQEQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Perfluorononanoic acid (PFNA) is a perfluoroalkyl substance (PFAS).1 It increases serum glucose and hepatic glycogen levels, as well as increases hepatic hydrogen peroxide and malondialdehyde (MDA) levels, in rats when administered at a dose of 5 mg/kg per day. PFNA induces spontaneous abortion in pregnant mice when administered at a dose of 10 mg/kg per day and leads to death of pups within 10 days when administered to dams at a dose of 5 mg/kg per day on gestational days 1 through 17.2 It has been found in bottled water, watersheds, and marine mammals.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fang, X., Gao, G., Xue, H., et al. Exposure of perfluorononanoic acid suppresses the hepatic insulin signal pathway and increases serum glucose in rats. Toxicology 294(2-3), 109-115 (2012).

    2. Das, K.P., Grey, B.E., Rosen, M.B., et al. Developmental toxicity of perfluorononanoic acid in mice. Reprod. Toxicol. 51, 133-144 (2015).

    3. Chow, S.J., Ojeda, N., Jacangelo, J.G., et al. Detection of ultrashort-chain and other per- and polyfluoroalkyl substances (PFAS) in U.S. bottled water. Water Res. 201, 117292 (2021).

    4. Pétré, M.-A., Salk, K.R., Stapleton, H.M., et al. Per- and polyfluoroalkyl substances (PFAS) in river discharge: Modeling loads upstream and downstream of a PFAS manufacturing plant in the Cape Fear watershed, North Carolina. Sci. Total Environ. 831, 154763 (2022).

    5. Rotander, A., Kärrman, A., van Bavel, B., et al. Increasing levels of long-chain perfluorocarboxylic acids (PFCAs) in Arctic and North Atlantic marine mammals, 1984-2009. Chemosphere 86(3), 278-285 (2012).