A perfluoroalkyl substance
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Perfluoropentanoic Acid

Item No. 37254

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2,3,3,4,4,5,5,5-nonafluoro-pentanoic acid
CAS Number
2706-90-3
Synonyms
  • Nonafluoropentanoic Acid
  • Nonafluorovaleric Acid
  • NSC 18404
  • Perfluorovaleric Acid
  • PFPeA
Molecular Formula
C5HF9O2
Formula Weight
264.0
Purity
≥85%
Formulation
A liquid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)O
InChi Code
InChI=1S/C5HF9O2/c6-2(7,1(15)16)3(8,9)4(10,11)5(12,13)14/h(H,15,16)
InChi Key
CXZGQIAOTKWCDB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Perfluoropentanoic acid is a perfluoroalkyl substance (PFAS).1 It activates peroxisome proliferator-activated receptor α (PPARα) in a reporter assay using COS-1 cells expressing the human receptor when used at concentrations ranging from 1 to 100 µM. Topical application of perfluoropentanoic acid (5% v/v) increases liver weight and the number of B cells, T cells, natural killer (NK) cells, eosinophils, and dendritic cells in the draining lymph node, decreases blood urea nitrogen (BUN) levels, and induces epidermal hyperplasia and hyperkeratosis in mice.2 It has been found in landfill leachate and sea and river water.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wolf, C.J., Schmid, J.E., Lau, C., et al. Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): Further investigation of C4-C12 compounds. Reprod Toxicol 33(4), 546-551 (2012).

    2. Weatherly, L.M., Shane, H.L., Lukomska, E., et al. Systemic toxicity induced by topical application of perfluoroheptanoic acid (PFHpA), perfluorohexanoic acid (PFHxA), and perfluoropentanoic acid (PFPeA) in a murine model. Food Chem. Toxicol. 171, 113515 (2023).

    3. Capozzi, S.L., Leang, A.L., Rodenburg, L.A., et al. PFAS in municipal landfill leachate: Occurrence, transformation, and sources. Chemosphere 334, 138924 (2023).

    4. Zhao, Z., Cheng, X., Hua, X., et al. Emerging and legacy per- and polyfluoroalkyl substances in water, sediment, and air of the Bohai Sea and its surrounding rivers. Environ. Pollut. 263(Pt. A), 114391 (2020).