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Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.
ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICESPerfluoroundecanoic acid is a perfluoroalkyl substance (PFAS).1 Embryo-larval exposure of perfluoroundecanoic acid decreases body length and eye size and increases yolk sac size in zebrafish when used at a concentration of 0.3 mg/L. Perfluoroundecanoic acid (1 mg/kg) decreases body and testicular weights and serum testosterone levels and increases serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in male mice.2 It also increases testicular malondialdehyde (MDA) levels and superoxide dismutase (SOD) and catalase activities in the same mice. Maternal serum levels of perfluoroundecanoic acid are positively associated with the risk of gestational diabetes.3 It has been found in surface freshwater foams and shellfish.4,5
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1. Thyroid disrupting effects of perfluoroundecanoic acid and perfluorotridecanoic acid in zebrafish (Danio rerio) and rat pituitary (GH3) cell line. Chemosphere 262, 128012 (2021).
2. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Chemosphere 338, 139491 (2023).
3. Exposure to per-
4. PFAS and dissolved organic carbon enrichment in surface water foams on a northern U.S. freshwater lake. Environ. Sci. Technol. 54(22), 14455-14464 (2020).
5. Perfluoroalkyl substances (PFASs) in the marine environment: Spatial distribution and temporal profile shifts in shellfish from French coasts. Chemosphere 228, (2019).