An AAK1 and BMP2K inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

LP-935509

Item No. 37283

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-(2-methoxy-3-pyridinyl)pyrazolo[1,5-a]pyrimidin-5-yl]-1-piperazinecarboxylic acid, 1-methylethyl ester
CAS Number
1454555-29-3
Molecular Formula
C20H24N6O3
Formula Weight
396.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
268, 308, 321 nm
SMILES
O=C(N1CCN(CC1)C2=NC3=C(C4=C(OC)N=CC=C4)C=NN3C=C2)OC(C)C
InChi Code
InChI=1S/C20H24N6O3/c1-14(2)29-20(27)25-11-9-24(10-12-25)17-6-8-26-18(23-17)16(13-22-26)15-5-4-7-21-19(15)28-3/h4-8,13-14H,9-12H2,1-3H3
InChi Key
GOOYSJIWTIHOGW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $44

    Add

    5 mg

    $176

    Add

    10 mg

    $329

    Add

    25 mg

    $657

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    LP-935509 is an inhibitor of AP2-associated protein kinase 1 (AAK1) and BMP2-inducible kinase (BMP2K; IC50s = 3.3 and 14 nM, respectively).1 It is selective for AAK1 and BMP2K over μ- and κ-opioid, as well as α2A- and α2C-adrenergic, receptors (IC50s = >30 µM for all), α1 and α2 subunit-containing GABAA receptors (IC50s = 12 µM for both), and cyclin G-associated kinase (GAK; IC50 = 0.32 µM). LP-935509 (1 µM) reduces phosphorylation of the synaptic vesicle regulator AP2 complex subunit Μu-1 (AP2M1) in SH-SY5Y neuroblastoma cells.2 It reduces the number of formalin-induced flinches in mice when administered at doses of 10, 30, and 60 mg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kostich, W., Hamman, B.D., Li, Y.-W., et al. Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain. J. Pharmacol. Exp. Ther. 358(3), 371-386 (2016).

    2. Liu, Q., Bautista-Gomez, J., Higgins, D.A., et al. Dysregulation ofthe AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration. Sci. Signal. 14(693), eabg3555 (2021).