A CYP1B1 inhibitor
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DMU2139

Item No. 37301

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(6-methoxy-2-naphthalenyl)-3-(3-pyridinyl)-2-propen-1-one
CAS Number
104890-70-2
Molecular Formula
C19H15NO2
Formula Weight
289.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/ml
λmax
232 nm
SMILES
O=C(C1=CC=C2C=C(C=CC2=C1)OC)C=CC3=CN=CC=C3
InChi Code
InChI=1S/C19H15NO2/c1-22-18-8-7-15-11-17(6-5-16(15)12-18)19(21)9-4-14-3-2-10-20-13-14/h2-13H,1H3
InChi Key
MPDPEUALCUWORP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $160

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    25 mg

    $267

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    50 mg

    $489

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    Cayman Chemical
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    Product Description

    DMU2139 is an inhibitor of the cytochrome P450 (CYP) isoform CYP1B1 (IC50 = 0.009 µM).1 It is selective for CYP1B1 over CYP1A1, CYP1A2, CYP3A4, and CYP2D6 (IC50s = 0.795, 1.2, 10.6, and 5 µM, respectively). DMU2139 enhances cisplatin-induced cell death in HEK293 cells overexpressing CYP1B1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Horley, N.J., Beresford, K.J.M., Chawla, T., et al. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur. J. Med. Chem. 129, 159-174 (2017).