An SST2 antagonist
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CYN 154806 (trifluoroacetate salt)

Item No. 37343

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Ac-4NO2-Phe-c(D-Cys-Tyr-D-Trp-Lys-Thr-Cys)-D-Tyr-NH2
Molecular Formula
C56H68N12O14S2 • XCF3COOH
Formula Weight
1197.3
Purity
≥90%
Formulation (Request formulation change)
A solid
Peptide Sequence
Ac-4-NO2-F-c(cYwKTC)-y-NH2
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 10 mg/mlEthanol: 25 mg/ml
SMILES
O=C([C@@H](NC([C@@H](CSSC[C@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)C(N[C@@H](C(N)=O)CC2=CC=C(C=C2)O)=O)NC([C@@H](NC(C)=O)CC3=CC=C(C=C3)[N+]([O-])=O)=O)=O)CC4=CC=C(C=C4)O)N[C@@H]1CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C56H68N12O14S2.C2HF3O2/c1-30(69)48-56(80)66-47(54(78)62-42(49(58)73)23-33-12-18-37(71)19-13-33)29-84-83-28-46(65-51(75)43(60-31(2)70)24-32-10-16-36(17-11-32)68(81)82)55(79)63-44(25-34-14-20-38(72)21-15-34)52(76)64-45(26-35-27-59-40-8-4-3-7-39(35)40)53(77)61-41(50(74)67-48)9-5-6-22-57;3-2(4,5)1(6)7/h3-4,7-8,10-21,27,30,41-48,59,69,71-72H,5-6,9,22-26,28-29,57H2,1-2H3,(H2,58,73)(H,60,70)(H,61,77)(H,62,78)(H,63,79)(H,64,76)(H,65,75)(H,66,80)(H,67,74);(H,6,7)/t30-,41+,42-,43+,44+,45-,46-,47+,48+;/m1./s1
InChi Key
FYVCFCQFOBEWIO-GVGJFGMUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $112

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    1 mg

    $212

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    5 mg

    $556

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    Product Description

    CYN 154806 is a cyclic peptide somatostatin receptor 2 (SST2) antagonist (IC50 = 2.62 nM).1 It is selective for SST2 over SST1, SST3, SST4, and SST5 (IC50s = 3,890, 851, 1,737, and 331 nM, respectively). CYN 154806 inhibits SST-induced increases in extracellular acidification (EAR) in CHO-K1 cells expressing recombinant human SST2 (pKB = 7.92) and [35S]GTPγS binding in CHO-K1 cell membranes expressing recombinant human SST2 (pKB = 7.81).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Feniuk, W., Jarvie, E., Luo, J., et al. Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology 39(8), 1443-1450 (2000).