An inhibitor of GSK3β
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2,4'-Dibromoacetophenone

Item No. 37358

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-bromo-1-(4-bromophenyl)-ethanone
CAS Number
99-73-0
Synonyms
  • GSK-3β Inhibitor VII
  • NSC 6224
Molecular Formula
C8H6Br2O
Formula Weight
277.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): insol
λmax
263 nm
SMILES
O=C(CBr)C1=CC=C(C=C1)Br
InChi Code
InChI=1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
InChi Key
FKJSFKCZZIXQIP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $36

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    $105

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    100 g

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    Product Description

    2,4’-Dibromoacetophenone is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 0.5 µM).1 It is selective for GSK3β over protein kinase A (PKA; IC50 = >100 µM). It has also been used in the derivatization of lactic acid and glycolic acid prior to analysis by HPLC.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Conde, S., Pérez, D.I., Martínez, A., et al. Thienyl and phenyl α-halomethyl ketones: New inhibitors of glycogen synthase kinase (GSK-3β) from a library of compound searching. J. Med. Chem. 46(22), 4631-4633 (2003).

    2. Pourasghar, M., Koenneke, A., Meiers, P., et al. Development of a fast and precise method for simultaneous quantification of the PLGA monomers lactic and glycolic acid by HPLC. J. Pharm. Anal. 9(2), 100-107 (2019).