A potential impurity in commercial preparations of losartan
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Losartan Azide

Item No. 37387

Technical Information
Formal Name
5-[4′-[[5-(azidomethyl)-2-butyl-4-chloro-1H-imidazol-1-yl]methyl][1,1′-biphenyl]-2-yl]-2H-tetrazole
CAS Number
727718-93-6
Molecular Formula
C22H22ClN9
Formula Weight
Purity
≥95%
A solid
SMILES
ClC1=C(CN=[N+]=[N-])N(CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)C(CCCC)=N1
InChi Code
InChI=1S/C22H22ClN9/c1-2-3-8-20-26-21(23)19(13-25-29-24)32(20)14-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-27-30-31-28-22/h4-7,9-12H,2-3,8,13-14H2,1H3,(H,27,28,30,31)
InChi Key
WSECDZBYSJWHFL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Losartan azide is a potential impurity in commercial preparations of the angiotensin II type 1 (AT1) receptor antagonist losartan.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Madasu, S.B., Vekariya, N.A., Koteswaramma, C., et alAn efficient, commercially viable, and safe process for preparation of losartan potassium, an angiotensin II receptor antagonist. Org. Process Res. Dev. 16(12), 2025−2030 (2012).