An anticancer agent and active metabolite of HMN-214
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Pro-drug Form(s)
26210HMN-214
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HMN-176

Item No. 37424

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methoxy-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-benzenesulfonamide
CAS Number
173529-10-7
Molecular Formula
C20H18N2O4S
Formula Weight
382.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 10 mg/mL
λmax
239, 343 nm
SMILES
O=S(NC1=C(C=CC=C1)/C=C/C(C=C2)=CC=N2=O)(C3=CC=C(C=C3)OC)=O
InChi Code
InChI=1S/C20H18N2O4S/c1-26-18-8-10-19(11-9-18)27(24,25)21-20-5-3-2-4-17(20)7-6-16-12-14-22(23)15-13-16/h2-15,21H,1H3/b7-6+
InChi Key
LBPNULPSVCDYRF-VOTSOKGWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $101

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    10 mg

    $191

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    25 mg

    $275

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    50 mg

    $500

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    Product Description

    HMN-176 is an anticancer agent and active metabolite of the prodrug HMN-214 (Item No. 26210).1 It is cytotoxic against a panel of cancer cell lines with a mean IC50 value of 112 nM, as well as P388 leukemia cells that are resistant to the DNA-crosslinking agent cisplatin (Item No. 13119), anthracycline antitumor antibiotic doxorubicin (Item No. 15007), or antimitotic vincristine (Item No. 11764) (IC50s = 143, 557, and 265 nM, respectively). HMN-176 (3 µM) induces cell cycle arrest at the G2/M phase in HeLa cervical cancer cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takagi, M., Honmura, T., Watanabe, S., et al. In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176. Invest. New Drugs 21(4), 387-399 (2003).